LGR5

Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameleucine rich repeat containing G protein-coupled receptor 5
OMIM IDMIM:606667
Ensembl IDEnsembl:ENSG00000139292
HGNC IDHGNC:HGNC:4504
PHARMGKB IDPA28894
Map Location12q21.1

GO terms in LGR5


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IDA GO:0005887 integral component of plasma membrane
CC IDA GO:0032588 trans-Golgi network membrane
BP IEA GO:0001942 hair follicle development
BP IEA GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: LGR5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined20Apoptosis regulation3Longevity regulating pathway1Ferroptosis1Th17 cell differentiation1Other, kinases1

Pathways in LGR5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-195721 Signaling by WNT
reactome R-HSA-201681 TCF dependent signaling in response to WNT
reactome R-HSA-4641263 Regulation of FZD by ubiquitination
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 3
iGMDRD147 Prima-1 1
iGMDRD60 Quinoclamine 1
iGMDRD888 Compound 44 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LGR5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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