LGR5


Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
leucine rich repeat containing G protein-coupled receptor 5MIM:606667Ensembl:ENSG00000139292HGNC:HGNC:4504PA2889412q21.1

GO terms in LGR5


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIDAGO:0032588trans-Golgi network membrane
BPIEAGO:0001942hair follicle development
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPIBAGO:0007190activation of adenylate cyclase activity
BPIBAGO:0009755hormone-mediated signaling pathway
BPIEAGO:0009994oocyte differentiation
BPIEAGO:0042127regulation of cell proliferation
BPIEAGO:0048839inner ear development
BPIDAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIEAGO:2001013epithelial cell proliferation involved in renal tubule morphogenesis
MFIDAGO:0004888transmembrane signaling receptor activity
MFIDAGO:0004930G-protein coupled receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008528G-protein coupled peptide receptor activity
MFIEAGO:0016500protein-hormone receptor activity

Gene expression in normal tissue: LGR5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LGR5


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-4641263Regulation of FZD by ubiquitination

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A3
iGMDRD147Prima-11
iGMDRD60Quinoclamine1
iGMDRD888Compound 442
iGMDRD506Fedratinib3
iGMDRD562Navitoclax2
iGMDRD780PP-306
iGMDRD398Sepantronium6
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16753
iGMDRD871BRD63684
iGMDRD887Compound 23 citrate4
iGMDRD441TW 372
iGMDRD870BRD636103
iGMDRD6AM-5803
iGMDRD270Ciclosporin1
iGMDRD211(1S,3R)-RSL33
iGMDRD280CYTOCHALASIN B6
iGMDRD679Bistramide A6
iGMDRD781Sirolimus4
iGMDRD779PRL-3 Inhibitor I2
iGMDRD670ML 2103
iGMDRD512nutlin 32
iGMDRD772BRD47702
iGMDRD84Lovastatin acid1
iGMDRD126Tipifarnib7
iGMDRD307Manumycin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LGR5

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