CDH15
Summary: This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cadherin 15 | MIM:114019 | Ensembl:ENSG00000129910 | HGNC:HGNC:1754 | PA26288 | 16q24.3 |
GO terms in CDH15
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008092 | cytoskeletal protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0045296 | cadherin binding |
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IBA | GO:0034332 | adherens junction organization |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IBA | GO:0044331 | cell-cell adhesion mediated by cadherin |
| BP | TAS | GO:0051149 | positive regulation of muscle cell differentiation |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005901 | caveola |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IBA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0016342 | catenin complex |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CDH15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDH15
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDH15
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