RBL1
Summary: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RB transcriptional corepressor like 1 | MIM:116957 | Ensembl:ENSG00000080839 | HGNC:HGNC:9893 | PA34257 | 20q11.23 |
GO terms in RBL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000785 | chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0043550 | regulation of lipid kinase activity |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IBA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| BP | IMP | GO:2000773 | negative regulation of cellular senescence |
| MF | IBA | GO:0001012 | RNA polymerase II regulatory region DNA binding |
| MF | IBA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: RBL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | e2f_pathway | E2F transcription factor network |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| netpath | Pathway_ID | ID |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP53 | ID signaling pathway |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | etspathway | mets affect on macrophage differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD138 | PX 12 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBL1
CLASSFICATION
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