RBL1


Summary: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RB transcriptional corepressor like 1MIM:116957Ensembl:ENSG00000080839HGNC:HGNC:9893PA3425720q11.23

GO terms in RBL1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000785chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005667transcription factor complex
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0007049cell cycle
BPIBAGO:0007346regulation of mitotic cell cycle
BPIMPGO:0010629negative regulation of gene expression
BPIEAGO:0016032viral process
BPIBAGO:0030154cell differentiation
BPIDAGO:0043550regulation of lipid kinase activity
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051726regulation of cell cycle
BPIBAGO:2000134negative regulation of G1/S transition of mitotic cell cycle
BPIMPGO:2000773negative regulation of cellular senescence
MFIBAGO:0001012RNA polymerase II regulatory region DNA binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001102RNA polymerase II activating transcription factor binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:1990841promoter-specific chromatin binding

Gene expression in normal tissue: RBL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RBL1


DatabasePathway IDPathway Des.
pide2f_pathwayE2F transcription factor network
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
netpathPathway_IDID
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
wikipathwaysWP179Cell Cycle
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP236Adipogenesis
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP53ID signaling pathway
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006936Signaling by TGF-beta family members
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartaetspathwaymets affect on macrophage differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD177Teniposide3
iGMDRD466Chaetocin1
iGMDRD61Kinetin riboside3
iGMDRD351GW843682X2
iGMDRD57Chloropentafluorobenzene2
iGMDRD639YK 4-2793
iGMDRD698Neratinib3
iGMDRD144NSC953973
iGMDRD670ML 2102
iGMDRD79Gemcitabine3
iGMDRD583LDN 1931892
iGMDRD210AC556491
iGMDRD84Lovastatin acid1
iGMDRD1008SR-II-138A6
iGMDRD263AACOCF32
iGMDRD886Compound 1541A2
iGMDRD451Serdemetan2
iGMDRD23Gossypol3
iGMDRD882CIL411
iGMDRD100Zebularine2
iGMDRD871BRD63683
iGMDRD562Navitoclax3
iGMDRD269Purmorphamine2
iGMDRD577BIX012943
iGMDRD506Fedratinib3
iGMDRD434BMS-5369243
iGMDRD207Capsaicin1
iGMDRD318PAC-12
iGMDRD202Curcumin2
iGMDRD158NSC1415403
iGMDRD138PX 123

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RBL1

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