NPR1


Summary: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
natriuretic peptide receptor 1MIM:108960Ensembl:ENSG00000169418HGNC:HGNC:7943PA317361q21.3

GO terms in NPR1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006182cGMP biosynthetic process
BPIDAGO:0006182cGMP biosynthetic process
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0007165signal transduction
BPNASGO:0007166cell surface receptor signaling pathway
BPIDAGO:0007168receptor guanylyl cyclase signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007589body fluid secretion
BPNASGO:0008217regulation of blood pressure
BPIBAGO:0009190cyclic nucleotide biosynthetic process
BPTASGO:0016525negative regulation of angiogenesis
BPNASGO:0030308negative regulation of cell growth
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0035810positive regulation of urine volume
BPTASGO:0035815positive regulation of renal sodium excretion
BPIEAGO:0042417dopamine metabolic process
BPTASGO:0043114regulation of vascular permeability
BPIEAGO:0048662negative regulation of smooth muscle cell proliferation
BPNASGO:0097746regulation of blood vessel diameter
BPTASGO:1903779regulation of cardiac conduction
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0008074guanylate cyclase complex, soluble
CCIEAGO:0016021integral component of membrane
CCIDAGO:0043235receptor complex
MFIBAGO:0004016adenylate cyclase activity
MFIBAGO:0004383guanylate cyclase activity
MFIDAGO:0004383guanylate cyclase activity
MFIEAGO:0004672protein kinase activity
MFIEAGO:0005524ATP binding
MFIEAGO:0005525GTP binding
MFNASGO:0008528G-protein coupled peptide receptor activity
MFIDAGO:0016941natriuretic peptide receptor activity
MFIPIGO:0017046peptide hormone binding
MFIEAGO:0019901protein kinase binding
MFIPIGO:0042562hormone binding

Gene expression in normal tissue: NPR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NPR1


DatabasePathway IDPathway Des.
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578768Physiological factors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD634SCHEMBL26080416
iGMDRD211(1S,3R)-RSL33
iGMDRD871BRD63684
iGMDRD441TW 371
iGMDRD213SMR0000686503
iGMDRD670ML 2103
iGMDRD103SN-388
iGMDRD84Lovastatin acid3
iGMDRD271Brefeldin A3
iGMDRD307Manumycin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPR1

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