RECQL4

Summary: The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRecQ like helicase 4
OMIM IDMIM:603780
Ensembl IDEnsembl:ENSG00000160957
HGNC IDHGNC:HGNC:9949
PHARMGKB IDPA34316
Map Location8q24.3

GO terms in RECQL4


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0000781 chromosome, telomeric region
CC IMP GO:0000781 chromosome, telomeric region
CC IBA GO:0005634 nucleus
CC IBA GO:0005694 chromosome
CC IBA GO:0005737 cytoplasm
CC HDA GO:0016020 membrane
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Gene expression in normal tissue: RECQL4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined16PI3K/MTOR signaling2Chromatin histone acetylation1Mitosis1Other, kinases1

Pathways in RECQL4


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD872 BRD7137 6
iGMDRD888 Compound 44 6
iGMDRD506 Fedratinib 1
iGMDRD329 Merck60 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RECQL4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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