MAML1

Summary: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemastermind like transcriptional coactivator 1
OMIM IDMIM:605424
Ensembl IDEnsembl:ENSG00000161021
HGNC IDHGNC:HGNC:13632
PHARMGKB IDPA30569
Map Location5q35.3

GO terms in MAML1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
CC IDA GO:0005634 nucleus
CC IBA GO:0005654 nucleoplasm
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0016607 nuclear speck
Showing 1 to 6 of 24 rows rows per page

Gene expression in normal tissue: MAML1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Apoptosis regulation2DNA replication1Protein stability and degradation1Cell cycle1Chromatin histone acetylation1RTK signaling1Other, kinases1p53 pathway1Proteasome1

Pathways in MAML1


Loading, please wait...
Database
Pathway ID
Pathway Des.
pid hes_heypathway Notch-mediated HES/HEY network
pid notch_pathway Notch signaling pathway
netpath Pathway_Notch Notch
kegg hsa04330 Notch signaling pathway - Homo sapiens (human)
kegg hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
kegg hsa05165 Human papillomavirus infection - Homo sapiens (human)
Showing 1 to 6 of 55 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD188 Piperlongumine 3
iGMDRD506 Fedratinib 3
iGMDRD398 Sepantronium 2
iGMDRD690 PRIMA-1MET 2
Showing 1 to 4 of 40 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAML1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.