MAML1


Summary: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mastermind like transcriptional coactivator 1MIM:605424Ensembl:ENSG00000161021HGNC:HGNC:13632PA305695q35.3

GO terms in MAML1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0002193MAML1-RBP-Jkappa- ICN1 complex
CCIDAGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0016607nuclear speck
CCIDAGO:0043231intracellular membrane-bounded organelle
BPISSGO:0003162atrioventricular node development
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0007219Notch signaling pathway
BPTASGO:0007219Notch signaling pathway
BPIBAGO:0007221positive regulation of transcription of Notch receptor target
BPTASGO:0007221positive regulation of transcription of Notch receptor target
BPIGIGO:0010831positive regulation of myotube differentiation
BPIEAGO:0045445myoblast differentiation
BPTASGO:0045747positive regulation of Notch signaling pathway
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0060928atrioventricular node cell development
MFIBAGO:0003713transcription coactivator activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0042605peptide antigen binding

Gene expression in normal tissue: MAML1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAML1


DatabasePathway IDPathway Des.
pidhes_heypathwayNotch-mediated HES/HEY network
pidnotch_pathwayNotch signaling pathway
netpathPathway_NotchNotch
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2197563NOTCH2 intracellular domain regulates transcription
reactomeR-HSA-2197563NOTCH2 intracellular domain regulates transcription
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-350054Notch-HLH transcription pathway
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine3
iGMDRD506Fedratinib3
iGMDRD398Sepantronium2
iGMDRD690PRIMA-1MET2
iGMDRD356PNU-746543
iGMDRD451Serdemetan2
iGMDRD444Tivantinib2
iGMDRD441TW 373
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-71
iGMDRD466Chaetocin3
iGMDRD394BX-7951
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib2
iGMDRD151CHM-13
iGMDRD554CHEMBL14341372
iGMDRD889Compound 7d-cis2
iGMDRD772BRD47703
iGMDRD427ABT7372
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16752
iGMDRD871BRD63682
iGMDRD872BRD71373
iGMDRD269Purmorphamine3
iGMDRD147Prima-12
iGMDRD246NPC268
iGMDRD42Vorinostat3
iGMDRD103SN-383
iGMDRD220fumonisin B11
iGMDRD121GMX17781
iGMDRD192CIL561
iGMDRD415LE-1351
iGMDRD351GW843682X3
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A3
iGMDRD512nutlin 32
iGMDRD148Pifithrin-mu2
iGMDRD424Tamatinib2
iGMDRD701NVP-AUY9222

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAML1

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