SEARCH

HOME / SEARCH / MAX

MAX

Summary: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
MYC associated factor X	MIM:154950	Ensembl:ENSG00000125952	HGNC:HGNC:6913	PA30656	14q23.3

Gene Categories:

CLINICALLY ACTIONABLE TRANSCRIPTION FACTOR COMPLEX

GO terms in MAX

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0000790	nuclear chromatin
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IEA	GO:0016605	PML body
CC	IEA	GO:0030425	dendrite
CC	IMP	GO:0032993	protein-DNA complex
CC	IDA	GO:0071339	MLL1 complex
CC	IBA	GO:0090575	RNA polymerase II transcription factor complex
CC	IDA	GO:0090575	RNA polymerase II transcription factor complex
BP	TAS	GO:0000082	G1/S transition of mitotic cell cycle
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	TAS	GO:0006366	transcription by RNA polymerase II
BP	IEA	GO:0009267	cellular response to starvation
BP	IEA	GO:0032868	response to insulin
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048678	response to axon injury
BP	IEA	GO:0051402	neuron apoptotic process
BP	IEA	GO:0060041	retina development in camera-type eye
BP	IEA	GO:0065003	protein-containing complex assembly
BP	TAS	GO:0070317	negative regulation of G0 to G1 transition
BP	IEA	GO:0071375	cellular response to peptide hormone stimulus
BP	IEA	GO:1903508	positive regulation of nucleic acid-templated transcription
MF	IBA	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
MF	IDA	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IBA	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MF	IBA	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IMP	GO:0003677	DNA binding
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	TAS	GO:0003712	transcription coregulator activity
MF	TAS	GO:0003713	transcription coactivator activity
MF	IPI	GO:0005515	protein binding
MF	IMP	GO:0042803	protein homodimerization activity
MF	IEA	GO:0044877	protein-containing complex binding
MF	IEA	GO:0046982	protein heterodimerization activity
MF	IMP	GO:0070888	E-box binding

Gene expression in normal tissue: MAX

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAX

Database	Pathway ID	Pathway Des.
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP400	p38 MAPK Signaling Pathway
pid	hdac_classi_pathway	Signaling events mediated by HDAC Class I
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
pid	myc_pathway	C-MYC pathway
pid	myc_represspathway	Validated targets of C-MYC transcriptional repression
pid	smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling
pid	telomerasepathway	Regulation of Telomerase
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
kegg	hsa05222	Small cell lung cancer - Homo sapiens (human)
biocarta	mapkpathway	mapkinase signaling pathway
biocarta	p38mapkpathway	p38 mapk signaling pathway
biocarta	tertpathway	overview of telomerase protein component gene htert transcriptional regulation
reactome	R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex
reactome	R-HSA-1538133	G0 and Early G1
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-453279	Mitotic G1-G1/S phases
reactome	R-HSA-69202	Cyclin E associated events during G1/S transition
reactome	R-HSA-69206	G1/S Transition
reactome	R-HSA-69242	S Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8953750	Transcriptional Regulation by E2F6

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD870	BRD63610	4
iGMDRD782	DC-45-A2	2
iGMDRD434	BMS-536924	2
iGMDRD84	Lovastatin acid	3
iGMDRD82	Quiflapon	3
iGMDRD886	Compound 1541A	2
iGMDRD61	Kinetin riboside	3
iGMDRD316	N9-Isopropyl-olomoucine	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAX

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.