SEARCH

HOME / SEARCH / CYB5R4

CYB5R4

Summary: NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cytochrome b5 reductase 4	MIM:608343	Ensembl:ENSG00000065615	HGNC:HGNC:20147	PA134904907	6q14.2

Gene Categories:

DRUGGABLE GENOME

GO terms in CYB5R4

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
MF	TAS	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
MF	IDA	GO:0016174	NAD(P)H oxidase activity
MF	IDA	GO:0016174	NAD(P)H oxidase activity
MF	IBA	GO:0016491	oxidoreductase activity
MF	IDA	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
MF	IEA	GO:0020037	heme binding
MF	IEA	GO:0046872	metal ion binding
MF	IBA	GO:0071949	FAD binding
CC	IBA	GO:0005783	endoplasmic reticulum
CC	IDA	GO:0005783	endoplasmic reticulum
CC	TAS	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0048471	perinuclear region of cytoplasm
BP	NAS	GO:0003032	detection of oxygen
BP	IBA	GO:0006091	generation of precursor metabolites and energy
BP	IDA	GO:0006091	generation of precursor metabolites and energy
BP	IBA	GO:0006801	superoxide metabolic process
BP	IDA	GO:0006801	superoxide metabolic process
BP	TAS	GO:0015701	bicarbonate transport
BP	ISS	GO:0030073	insulin secretion
BP	ISS	GO:0042593	glucose homeostasis
BP	ISS	GO:0046677	response to antibiotic
BP	ISS	GO:0048468	cell development
BP	IDA	GO:0055114	oxidation-reduction process

Gene expression in normal tissue: CYB5R4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYB5R4

Database	Pathway ID	Pathway Des.
kegg	hsa00520	Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
wikipathways	WP43	Oxidation by Cytochrome P450
reactome	R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen
reactome	R-HSA-1480926	O2/CO2 exchange in erythrocytes
reactome	R-HSA-382551	Transport of small molecules

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD505	Pevonedistat	2
iGMDRD552	AZD-1775	3
iGMDRD263	AACOCF3	3
iGMDRD147	Prima-1	1
iGMDRD366	PI-103	1
iGMDRD882	CIL41	1
iGMDRD481	Dactolisib	1
iGMDRD267	Oligomycin A	1
iGMDRD289	Parthenolide	3
iGMDRD105	Triptolide	5
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD202	Curcumin	3
iGMDRD154	NSC23766	3
iGMDRD945	ML214	2
iGMDRD901	ELCPK	1
iGMDRD698	Neratinib	6
iGMDRD405	PIK-75	3
iGMDRD424	Tamatinib	3
iGMDRD512	nutlin 3	1
iGMDRD84	Lovastatin acid	3
iGMDRD486	Tosedostat	8
iGMDRD369	TGX-115	3
iGMDRD60	Quinoclamine	2
iGMDRD577	BIX01294	6
iGMDRD888	Compound 44	2
iGMDRD780	PP-30	1
iGMDRD398	Sepantronium	3
iGMDRD562	Navitoclax	2
iGMDRD188	Piperlongumine	3
iGMDRD887	Compound 23 citrate	5
iGMDRD399	Selumetinib	4
iGMDRD318	PAC-1	10
iGMDRD870	BRD63610	2
iGMDRD207	Capsaicin	1
iGMDRD782	DC-45-A2	2
iGMDRD802	4-methylfasudil	4
iGMDRD466	Chaetocin	4
iGMDRD394	BX-795	2
iGMDRD280	CYTOCHALASIN B	8
iGMDRD316	N9-Isopropyl-olomoucine	3
iGMDRD152	179324-69-7	2
iGMDRD61	Kinetin riboside	3
iGMDRD781	Sirolimus	3
iGMDRD427	ABT737	2
iGMDRD144	NSC95397	6
iGMDRD387	CHIR-99021	2
iGMDRD772	BRD4770	6
iGMDRD126	Tipifarnib	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYB5R4

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.