CYB5R4

Summary: NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecytochrome b5 reductase 4
OMIM IDMIM:608343
Ensembl IDEnsembl:ENSG00000065615
HGNC IDHGNC:HGNC:20147
PHARMGKB IDPA134904907
Map Location6q14.2

Gene Categories:

DRUGGABLE GENOME

GO terms in CYB5R4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
MF TAS GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
MF IDA GO:0016174 NAD(P)H oxidase activity
MF IDA GO:0016174 NAD(P)H oxidase activity
MF IBA GO:0016491 oxidoreductase activity
MF IDA GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
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Gene expression in normal tissue: CYB5R4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined36Apoptosis regulation3PI3K/MTOR signaling2Longevity regulating pathway1WNT signaling1Proteasome1ERK MAPK signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Chromatin histone acetylation1Metabolic pathways1

Pathways in CYB5R4


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Database
Pathway ID
Pathway Des.
kegg hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
wikipathways WP43 Oxidation by Cytochrome P450
reactome R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen
reactome R-HSA-1480926 O2/CO2 exchange in erythrocytes
reactome R-HSA-382551 Transport of small molecules
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD505 Pevonedistat 2
iGMDRD552 AZD-1775 3
iGMDRD263 AACOCF3 3
iGMDRD147 Prima-1 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYB5R4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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