EPHB2
Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
NameEPH receptor B2 OMIM IDMIM:600997 Ensembl IDEnsembl:ENSG00000133216 HGNC IDHGNC:HGNC:3393 PHARMGKB IDPA27825 Map Location1p36.12 |
GO terms in EPHB2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISS | GO:0001540 | amyloid-beta binding |
MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
MF | EXP | GO:0004713 | protein tyrosine kinase activity |
MF | IBA | GO:0004713 | protein tyrosine kinase activity |
MF | ISS | GO:0004713 | protein tyrosine kinase activity |
MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
Gene expression in normal tissue: EPHB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-373760 | L1CAM interactions |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |