EPHB2


Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600997
PHARMGKB IDPA27825
Map Location1p36.12

GO terms in EPHB2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0001540 amyloid-beta binding
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF EXP GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF ISS GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
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Gene expression in normal tissue: EPHB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHB2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-373760 L1CAM interactions
reactome R-HSA-3928662 EPHB-mediated forward signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD506 Fedratinib 3
iGMDRD562 Navitoclax 3
iGMDRD286 Nsc 632839 3
iGMDRD874 BRD8958 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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