PDK4

Summary: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepyruvate dehydrogenase kinase 4
OMIM IDMIM:602527
Ensembl IDEnsembl:ENSG00000004799
HGNC IDHGNC:HGNC:8812
PHARMGKB IDPA33157
Map Location7q21.3

GO terms in PDK4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006006 glucose metabolic process
BP IEA GO:0006468 protein phosphorylation
BP ISS GO:0006885 regulation of pH
BP IMP GO:0008286 insulin receptor signaling pathway
BP IDA GO:0009267 cellular response to starvation
BP IMP GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
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Gene expression in normal tissue: PDK4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 40BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 9

Gene-drug pathway distribution

undefined21p53 pathway1Protein stability and degradation1

Pathways in PDK4


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Database
Pathway ID
Pathway Des.
wikipathways WP2881 Estrogen Receptor Pathway
wikipathways WP2882 Nuclear Receptors Meta-Pathway
wikipathways WP3925 Amino Acid metabolism
reactome R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD116 CD437 3
iGMDRD494 Neopeltolide 2
iGMDRD330 BRD4132 2
iGMDRD84 Lovastatin acid 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDK4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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