PDK4
Summary: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602527 Ensembl IDEnsembl:ENSG00000004799 HGNC IDHGNC:HGNC:8812 PHARMGKB IDPA33157 Map Location7q21.3 |
GO terms in PDK4
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0006006 | glucose metabolic process |
BP | IEA | GO:0006468 | protein phosphorylation |
BP | ISS | GO:0006885 | regulation of pH |
BP | IMP | GO:0008286 | insulin receptor signaling pathway |
BP | IDA | GO:0009267 | cellular response to starvation |
BP | IMP | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
Gene expression in normal tissue: PDK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDK4
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2881 | Estrogen Receptor Pathway |
wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
wikipathways | WP3925 | Amino Acid metabolism |
reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PDK4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |