SMAD2


Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601366
PHARMGKB IDPA134959722
Map Location18q21.1

GO terms in SMAD2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000790 nuclear chromatin
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005667 transcription factor complex
CC IDA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
Showing 1 to 6 of 91 rows rows per page

Gene expression in normal tissue: SMAD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Other, kinases2Ferroptosis2Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Apoptosis regulation1Longevity regulating pathway1

Pathways in SMAD2


Loading, please wait...
Database
Pathway ID
Pathway Des.
biocarta tgfbpathway tgf beta signaling pathway
reactome R-HSA-1181150 Signaling by NODAL
reactome R-HSA-1181150 Signaling by NODAL
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1502540 Signaling by Activin
Showing 1 to 6 of 83 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 2
iGMDRD670 ML 210 3
iGMDRD772 BRD4770 2
iGMDRD425 ERASTIN 2
Showing 1 to 4 of 38 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​