BRF2
Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BRF2, RNA polymerase III transcription initiation factor subunit | MIM:607013 | Ensembl:ENSG00000104221 | HGNC:HGNC:17298 | PA164741329 | 8p11.23 |
GO terms in BRF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001032 | RNA polymerase III type 3 promoter DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IMP | GO:0000126 | transcription factor TFIIIB complex |
| CC | TAS | GO:0005654 | nucleoplasm |
| BP | IMP | GO:0006359 | regulation of transcription by RNA polymerase III |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | IEA | GO:0070897 | DNA-templated transcriptional preinitiation complex assembly |
Gene expression in normal tissue: BRF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-74158 | RNA Polymerase III Transcription |
| reactome | R-HSA-74158 | RNA Polymerase III Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation |
| reactome | R-HSA-76046 | RNA Polymerase III Transcription Initiation |
| reactome | R-HSA-76046 | RNA Polymerase III Transcription Initiation |
| reactome | R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| reactome | R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD780 | PP-30 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD885 | Compound 110 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRF2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.