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BRF2

Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameBRF2, RNA polymerase III transcription initiation factor subunit OMIM IDMIM:607013 Ensembl IDEnsembl:ENSG00000104221 HGNC IDHGNC:HGNC:17298 PHARMGKB IDPA164741329 Map Location8p11.23

GO terms in BRF2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0001032	RNA polymerase III type 3 promoter DNA binding
MF	IEA	GO:0046872	metal ion binding
CC	IMP	GO:0000126	transcription factor TFIIIB complex
CC	TAS	GO:0005654	nucleoplasm
BP	IMP	GO:0006359	regulation of transcription by RNA polymerase III
BP	IMP	GO:0034599	cellular response to oxidative stress

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Gene expression in normal tissue: BRF2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRF2

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-74158	RNA Polymerase III Transcription
reactome	R-HSA-74158	RNA Polymerase III Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation
reactome	R-HSA-76046	RNA Polymerase III Transcription Initiation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD780	PP-30	3
iGMDRD887	Compound 23 citrate	3
iGMDRD882	CIL41	3
iGMDRD132	(-)-gallocatechin-3-O-gallate	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRF2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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