HIF1A
Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hypoxia inducible factor 1 subunit alpha | MIM:603348 | Ensembl:ENSG00000100644 | HGNC:HGNC:4910 | PA29283 | 14q23.2 |
GO terms in HIF1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IDA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0035035 | histone acetyltransferase binding |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | TAS | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0051879 | Hsp90 protein binding |
| MF | IEA | GO:0070888 | E-box binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IMP | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001755 | neural crest cell migration |
| BP | ISS | GO:0001837 | epithelial to mesenchymal transition |
| BP | IEA | GO:0001892 | embryonic placenta development |
| BP | IEA | GO:0001922 | B-1 B cell homeostasis |
| BP | IC | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IEA | GO:0001947 | heart looping |
| BP | IEA | GO:0002052 | positive regulation of neuroblast proliferation |
| BP | ISS | GO:0002248 | connective tissue replacement involved in inflammatory response wound healing |
| BP | IEA | GO:0003151 | outflow tract morphogenesis |
| BP | IEA | GO:0003208 | cardiac ventricle morphogenesis |
| BP | IEA | GO:0006089 | lactate metabolic process |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006879 | cellular iron ion homeostasis |
| BP | IMP | GO:0007165 | signal transduction |
| BP | IEA | GO:0007595 | lactation |
| BP | IEA | GO:0008542 | visual learning |
| BP | IEP | GO:0010039 | response to iron ion |
| BP | IDA | GO:0010468 | regulation of gene expression |
| BP | IDA | GO:0010573 | vascular endothelial growth factor production |
| BP | IDA | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IMP | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | ISS | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IMP | GO:0010870 | positive regulation of receptor biosynthetic process |
| BP | IEA | GO:0014850 | response to muscle activity |
| BP | IEA | GO:0016239 | positive regulation of macroautophagy |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0019896 | axonal transport of mitochondrion |
| BP | IEA | GO:0021502 | neural fold elevation formation |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | IEA | GO:0030502 | negative regulation of bone mineralization |
| BP | IC | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0032007 | negative regulation of TOR signaling |
| BP | IDA | GO:0032364 | oxygen homeostasis |
| BP | TAS | GO:0032722 | positive regulation of chemokine production |
| BP | IMP | GO:0032909 | regulation of transforming growth factor beta2 production |
| BP | ISS | GO:0032963 | collagen metabolic process |
| BP | IEA | GO:0035162 | embryonic hemopoiesis |
| BP | IEA | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0042541 | hemoglobin biosynthetic process |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | IC | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IC | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IC | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IC | GO:0045821 | positive regulation of glycolytic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045926 | negative regulation of growth |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046716 | muscle cell cellular homeostasis |
| BP | IDA | GO:0046886 | positive regulation of hormone biosynthetic process |
| BP | IEA | GO:0048546 | digestive tract morphogenesis |
| BP | TAS | GO:0051000 | positive regulation of nitric-oxide synthase activity |
| BP | IEA | GO:0051216 | cartilage development |
| BP | ISS | GO:0051541 | elastin metabolic process |
| BP | IEA | GO:0060574 | intestinal epithelial cell maturation |
| BP | IEA | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development |
| BP | IEA | GO:0061072 | iris morphogenesis |
| BP | IEA | GO:0061298 | retina vasculature development in camera-type eye |
| BP | TAS | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | IDA | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | IMP | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | IC | GO:0070101 | positive regulation of chemokine-mediated signaling pathway |
| BP | IEA | GO:0070244 | negative regulation of thymocyte apoptotic process |
| BP | IEP | GO:0071347 | cellular response to interleukin-1 |
| BP | IDA | GO:0071456 | cellular response to hypoxia |
| BP | IEP | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071542 | dopaminergic neuron differentiation |
| BP | IEA | GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway |
| BP | IMP | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| BP | IEA | GO:1903599 | positive regulation of autophagy of mitochondrion |
| BP | IEA | GO:1903715 | regulation of aerobic respiration |
| BP | IEA | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| BP | IEA | GO:2001054 | negative regulation of mesenchymal cell apoptotic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IPI | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | ISS | GO:0016607 | nuclear speck |
| CC | IEA | GO:0031514 | motile cilium |
| CC | IMP | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0090575 | RNA polymerase II transcription factor complex |
| CC | IEA | GO:1904115 | axon cytoplasm |
Gene expression in normal tissue: HIF1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIF1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor |
| reactome | R-HSA-1234162 | Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849473 | PTK6 Expression |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif1apathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| netpath | Pathway_RAGE | RAGE |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2456 | HIF1A and PPARG regulation of glycolysis |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3593 | miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3672 | LncRNA-mediated mechanisms of therapeutic resistance |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| smpdb | SMP02292 | The oncogenic action of Succinate |
| smpdb | SMP02295 | The oncogenic action of Fumarate |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HIF1A
CLASSFICATION
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