HIF1A


Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
hypoxia inducible factor 1 subunit alphaMIM:603348Ensembl:ENSG00000100644HGNC:HGNC:4910PA2928314q23.2

GO terms in HIF1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIDAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0035035histone acetyltransferase binding
MFIPIGO:0035257nuclear hormone receptor binding
MFIEAGO:0042826histone deacetylase binding
MFIDAGO:0043565sequence-specific DNA binding
MFIPIGO:0046982protein heterodimerization activity
MFTASGO:0046982protein heterodimerization activity
MFIDAGO:0051879Hsp90 protein binding
MFIEAGO:0070888E-box binding
BPIEAGO:0001525angiogenesis
BPIDAGO:0001666response to hypoxia
BPIMPGO:0001666response to hypoxia
BPIEAGO:0001755neural crest cell migration
BPISSGO:0001837epithelial to mesenchymal transition
BPIEAGO:0001892embryonic placenta development
BPIEAGO:0001922B-1 B cell homeostasis
BPICGO:0001938positive regulation of endothelial cell proliferation
BPIEAGO:0001947heart looping
BPIEAGO:0002052positive regulation of neuroblast proliferation
BPISSGO:0002248connective tissue replacement involved in inflammatory response wound healing
BPIEAGO:0003151outflow tract morphogenesis
BPIEAGO:0003208cardiac ventricle morphogenesis
BPIEAGO:0006089lactate metabolic process
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0006366transcription by RNA polymerase II
BPIEAGO:0006879cellular iron ion homeostasis
BPIMPGO:0007165signal transduction
BPIEAGO:0007595lactation
BPIEAGO:0008542visual learning
BPIEPGO:0010039response to iron ion
BPIDAGO:0010468regulation of gene expression
BPIDAGO:0010573vascular endothelial growth factor production
BPIDAGO:0010575positive regulation of vascular endothelial growth factor production
BPIMPGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010628positive regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPISSGO:0010634positive regulation of epithelial cell migration
BPIMPGO:0010870positive regulation of receptor biosynthetic process
BPIEAGO:0014850response to muscle activity
BPIEAGO:0016239positive regulation of macroautophagy
BPTASGO:0016579protein deubiquitination
BPTASGO:0019221cytokine-mediated signaling pathway
BPIMPGO:0019896axonal transport of mitochondrion
BPIEAGO:0021502neural fold elevation formation
BPIEAGO:0021987cerebral cortex development
BPIEAGO:0030502negative regulation of bone mineralization
BPICGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0032007negative regulation of TOR signaling
BPIDAGO:0032364oxygen homeostasis
BPTASGO:0032722positive regulation of chemokine production
BPIMPGO:0032909regulation of transforming growth factor beta2 production
BPISSGO:0032963collagen metabolic process
BPIEAGO:0035162embryonic hemopoiesis
BPIEAGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0042541hemoglobin biosynthetic process
BPIEAGO:0042593glucose homeostasis
BPICGO:0042789mRNA transcription by RNA polymerase II
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPIDAGO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress
BPTASGO:0043687post-translational protein modification
BPICGO:0045648positive regulation of erythrocyte differentiation
BPICGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPICGO:0045821positive regulation of glycolytic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045926negative regulation of growth
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046716muscle cell cellular homeostasis
BPIDAGO:0046886positive regulation of hormone biosynthetic process
BPIEAGO:0048546digestive tract morphogenesis
BPTASGO:0051000positive regulation of nitric-oxide synthase activity
BPIEAGO:0051216cartilage development
BPISSGO:0051541elastin metabolic process
BPIEAGO:0060574intestinal epithelial cell maturation
BPIEAGO:0061030epithelial cell differentiation involved in mammary gland alveolus development
BPIEAGO:0061072iris morphogenesis
BPIEAGO:0061298retina vasculature development in camera-type eye
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPIDAGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPIMPGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPICGO:0070101positive regulation of chemokine-mediated signaling pathway
BPIEAGO:0070244negative regulation of thymocyte apoptotic process
BPIEPGO:0071347cellular response to interleukin-1
BPIDAGO:0071456cellular response to hypoxia
BPIEPGO:0071456cellular response to hypoxia
BPIEAGO:0071542dopaminergic neuron differentiation
BPIEAGO:0097411hypoxia-inducible factor-1alpha signaling pathway
BPIMPGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIDAGO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
BPIEAGO:1903599positive regulation of autophagy of mitochondrion
BPIEAGO:1903715regulation of aerobic respiration
BPIEAGO:2000378negative regulation of reactive oxygen species metabolic process
BPIEAGO:2001054negative regulation of mesenchymal cell apoptotic process
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIPIGO:0005667transcription factor complex
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016604nuclear body
CCISSGO:0016607nuclear speck
CCIEAGO:0031514motile cilium
CCIMPGO:0032991protein-containing complex
CCIDAGO:0090575RNA polymerase II transcription factor complex
CCIEAGO:1904115axon cytoplasm

Gene expression in normal tissue: HIF1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIF1A


DatabasePathway IDPathway Des.
reactomeR-HSA-1234158Regulation of gene expression by Hypoxia-inducible Factor
reactomeR-HSA-1234162Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849473PTK6 Expression
reactomeR-HSA-8857538PTK6 promotes HIF1A stabilization
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
biocartaeponfkbpathwayerythropoietin mediated neuroprotection through nf-kb
biocartahifpathwayhypoxia-inducible factor in the cardivascular system
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartavegfpathwayvegf hypoxia and angiogenesis
pidap1_pathwayAP-1 transcription factor network
pidhes_heypathwayNotch-mediated HES/HEY network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidhif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha
pidvegfr1_pathwayVEGFR1 specific signals
netpathPathway_RAGERAGE
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
wikipathwaysWP1539Angiogenesis
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2456HIF1A and PPARG regulation of glycolysis
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3593miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3672LncRNA-mediated mechanisms of therapeutic resistance
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP61Notch Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
smpdbSMP02292The oncogenic action of Succinate
smpdbSMP02295The oncogenic action of Fumarate

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD414MST-3123
iGMDRD237ABT-7512
iGMDRD61Kinetin riboside5
iGMDRD351GW843682X5
iGMDRD241Sunitinib1
iGMDRD427ABT7371
iGMDRD105Triptolide3
iGMDRD781Sirolimus3
iGMDRD397Pazopanib1
iGMDRD870BRD636101
iGMDRD231Importazole4
iGMDRD441TW 371
iGMDRD84Lovastatin acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIF1A

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