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ROBO1

Summary: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
roundabout guidance receptor 1	MIM:602430	Ensembl:ENSG00000169855	HGNC:HGNC:10249	PA34620	3p12.3

Gene Categories:

PROTEASE SERINE THREONINE KINASE KINASE CELL SURFACE

GO terms in ROBO1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0008046	axon guidance receptor activity
MF	IPI	GO:0030275	LRR domain binding
MF	IDA	GO:0042802	identical protein binding
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0009986	cell surface
CC	IEA	GO:0030424	axon
BP	IMP	GO:0002042	cell migration involved in sprouting angiogenesis
BP	ISS	GO:0003148	outflow tract septum morphogenesis
BP	ISS	GO:0003180	aortic valve morphogenesis
BP	ISS	GO:0003184	pulmonary valve morphogenesis
BP	ISS	GO:0003272	endocardial cushion formation
BP	IMP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	TAS	GO:0007155	cell adhesion
BP	IDA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	TAS	GO:0007399	nervous system development
BP	TAS	GO:0007411	axon guidance
BP	ISS	GO:0010628	positive regulation of gene expression
BP	ISS	GO:0010629	negative regulation of gene expression
BP	ISS	GO:0016199	axon midline choice point recognition
BP	IDA	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
BP	IMP	GO:0030336	negative regulation of cell migration
BP	IMP	GO:0033600	negative regulation of mammary gland epithelial cell proliferation
BP	IMP	GO:0035025	positive regulation of Rho protein signal transduction
BP	IMP	GO:0035385	Roundabout signaling pathway
BP	ISS	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction
BP	ISS	GO:0035904	aorta development
BP	IMP	GO:0043406	positive regulation of MAP kinase activity
BP	IDA	GO:0050772	positive regulation of axonogenesis
BP	IDA	GO:0050925	negative regulation of negative chemotaxis
BP	ISS	GO:0060412	ventricular septum morphogenesis
BP	IMP	GO:0070100	negative regulation of chemokine-mediated signaling pathway
BP	IMP	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway

Gene expression in normal tissue: ROBO1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ROBO1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-373752	Netrin-1 signaling
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-428540	Activation of RAC1
reactome	R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO
reactome	R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO
reactome	R-HSA-428543	Inactivation of CDC42 and RAC1
reactome	R-HSA-428890	Role of ABL in ROBO-SLIT signaling
reactome	R-HSA-428890	Role of ABL in ROBO-SLIT signaling
reactome	R-HSA-8985586	SLIT2:ROBO1 increases RHOA activity
reactome	R-HSA-8985801	Regulation of cortical dendrite branching
reactome	R-HSA-9010553	Regulation of expression of SLITs and ROBOs
reactome	R-HSA-9010553	Regulation of expression of SLITs and ROBOs
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
kegg	hsa04360	Axon guidance - Homo sapiens (human)
wikipathways	WP1993	Angiogenesis overview

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD887	Compound 23 citrate	4
iGMDRD399	Selumetinib	2
iGMDRD188	Piperlongumine	4
iGMDRD100	Zebularine	5
iGMDRD398	Sepantronium	2
iGMDRD64	Parbendazole	6
iGMDRD60	Quinoclamine	3
iGMDRD23	Gossypol	2
iGMDRD356	PNU-74654	2
iGMDRD268	Cerulenin	3
iGMDRD138	PX 12	6
iGMDRD270	Ciclosporin	2
iGMDRD260	FQI-2	6
iGMDRD255	SB225002	2
iGMDRD870	BRD63610	1
iGMDRD318	PAC-1	2
iGMDRD446	LY 2183240	2
iGMDRD193	Fqi1	4
iGMDRD152	179324-69-7	1
iGMDRD639	YK 4-279	2
iGMDRD280	CYTOCHALASIN B	5
iGMDRD466	Chaetocin	2
iGMDRD433	Lexibulin	3
iGMDRD151	CHM-1	7
iGMDRD126	Tipifarnib	2
iGMDRD425	ERASTIN	3
iGMDRD889	Compound 7d-cis	4
iGMDRD427	ABT737	2
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD781	Sirolimus	5
iGMDRD484	Pluripotin	1
iGMDRD872	BRD7137	2
iGMDRD871	BRD6368	4
iGMDRD67	PENFLURIDOL	3
iGMDRD286	Nsc 632839	6
iGMDRD414	MST-312	6
iGMDRD662	JQ-1	3
iGMDRD329	Merck60	2
iGMDRD552	AZD-1775	1
iGMDRD505	Pevonedistat	2
iGMDRD886	Compound 1541A	2
iGMDRD121	GMX1778	2
iGMDRD103	SN-38	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD434	BMS-536924	4
iGMDRD705	Nakiterpiosin	5
iGMDRD6	AM-580	4
iGMDRD105	Triptolide	3
iGMDRD77	Itraconazole	5
iGMDRD213	SMR000068650	2
iGMDRD85	Ursolic acid	3
iGMDRD237	ABT-751	1
iGMDRD351	GW843682X	2
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD123	Isoevodiamine	6
iGMDRD132	(-)-gallocatechin-3-O-gallate	3
iGMDRD945	ML214	2
iGMDRD84	Lovastatin acid	5
iGMDRD424	Tamatinib	3
iGMDRD560	MK-2206	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ROBO1

SITE

DATATYPES

CLASSFICATION

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