ROBO1


Summary: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
roundabout guidance receptor 1MIM:602430Ensembl:ENSG00000169855HGNC:HGNC:10249PA346203p12.3

GO terms in ROBO1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0008046axon guidance receptor activity
MFIPIGO:0030275LRR domain binding
MFIDAGO:0042802identical protein binding
CCIDAGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0030424axon
BPIMPGO:0002042cell migration involved in sprouting angiogenesis
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003180aortic valve morphogenesis
BPISSGO:0003184pulmonary valve morphogenesis
BPISSGO:0003272endocardial cushion formation
BPIMPGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0007155cell adhesion
BPIDAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPTASGO:0007399nervous system development
BPTASGO:0007411axon guidance
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0010629negative regulation of gene expression
BPISSGO:0016199axon midline choice point recognition
BPIDAGO:0021836chemorepulsion involved in postnatal olfactory bulb interneuron migration
BPIMPGO:0030336negative regulation of cell migration
BPIMPGO:0033600negative regulation of mammary gland epithelial cell proliferation
BPIMPGO:0035025positive regulation of Rho protein signal transduction
BPIMPGO:0035385Roundabout signaling pathway
BPISSGO:0035481positive regulation of Notch signaling pathway involved in heart induction
BPISSGO:0035904aorta development
BPIMPGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0050772positive regulation of axonogenesis
BPIDAGO:0050925negative regulation of negative chemotaxis
BPISSGO:0060412ventricular septum morphogenesis
BPIMPGO:0070100negative regulation of chemokine-mediated signaling pathway
BPIMPGO:1900748positive regulation of vascular endothelial growth factor signaling pathway

Gene expression in normal tissue: ROBO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ROBO1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428540Activation of RAC1
reactomeR-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBO
reactomeR-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBO
reactomeR-HSA-428543Inactivation of CDC42 and RAC1
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
reactomeR-HSA-8985586SLIT2:ROBO1 increases RHOA activity
reactomeR-HSA-8985801Regulation of cortical dendrite branching
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
kegghsa04360Axon guidance - Homo sapiens (human)
wikipathwaysWP1993Angiogenesis overview

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD887Compound 23 citrate4
iGMDRD399Selumetinib2
iGMDRD188Piperlongumine4
iGMDRD100Zebularine5
iGMDRD398Sepantronium2
iGMDRD64Parbendazole6
iGMDRD60Quinoclamine3
iGMDRD23Gossypol2
iGMDRD356PNU-746542
iGMDRD268Cerulenin3
iGMDRD138PX 126
iGMDRD270Ciclosporin2
iGMDRD260FQI-26
iGMDRD255SB2250022
iGMDRD870BRD636101
iGMDRD318PAC-12
iGMDRD446LY 21832402
iGMDRD193Fqi14
iGMDRD152179324-69-71
iGMDRD639YK 4-2792
iGMDRD280CYTOCHALASIN B5
iGMDRD466Chaetocin2
iGMDRD433Lexibulin3
iGMDRD151CHM-17
iGMDRD126Tipifarnib2
iGMDRD425ERASTIN3
iGMDRD889Compound 7d-cis4
iGMDRD427ABT7372
iGMDRD779PRL-3 Inhibitor I2
iGMDRD781Sirolimus5
iGMDRD484Pluripotin1
iGMDRD872BRD71372
iGMDRD871BRD63684
iGMDRD67PENFLURIDOL3
iGMDRD286Nsc 6328396
iGMDRD414MST-3126
iGMDRD662JQ-13
iGMDRD329Merck602
iGMDRD552AZD-17751
iGMDRD505Pevonedistat2
iGMDRD886Compound 1541A2
iGMDRD121GMX17782
iGMDRD103SN-382
iGMDRD5Tyrphostin AG 14782
iGMDRD434BMS-5369244
iGMDRD705Nakiterpiosin5
iGMDRD6AM-5804
iGMDRD105Triptolide3
iGMDRD77Itraconazole5
iGMDRD213SMR0000686502
iGMDRD85Ursolic acid3
iGMDRD237ABT-7511
iGMDRD351GW843682X2
iGMDRD57Chloropentafluorobenzene2
iGMDRD123Isoevodiamine6
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD945ML2142
iGMDRD84Lovastatin acid5
iGMDRD424Tamatinib3
iGMDRD560MK-22063

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ROBO1

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