PGGT1B
Summary: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein geranylgeranyltransferase type I subunit beta | MIM:602031 | Ensembl:ENSG00000164219 | HGNC:HGNC:8895 | PA33233 | 5q22.3 |
GO terms in PGGT1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0018342 | protein prenylation |
| BP | IBA | GO:0018344 | protein geranylgeranylation |
| BP | IDA | GO:0018344 | protein geranylgeranylation |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process |
| CC | IBA | GO:0005953 | CAAX-protein geranylgeranyltransferase complex |
| CC | IDA | GO:0005953 | CAAX-protein geranylgeranyltransferase complex |
| MF | IBA | GO:0004659 | prenyltransferase activity |
| MF | IDA | GO:0004661 | protein geranylgeranyltransferase activity |
| MF | IBA | GO:0004662 | CAAX-protein geranylgeranyltransferase activity |
| MF | ISS | GO:0004662 | CAAX-protein geranylgeranyltransferase activity |
| MF | IEA | GO:0008144 | drug binding |
| MF | ISS | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0019840 | isoprenoid binding |
| MF | IEA | GO:0042277 | peptide binding |
Gene expression in normal tissue: PGGT1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PGGT1B
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD882 | CIL41 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD781 | Sirolimus | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PGGT1B
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.