PGGT1B
Summary: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602031 Ensembl IDEnsembl:ENSG00000164219 HGNC IDHGNC:HGNC:8895 PHARMGKB IDPA33233 Map Location5q22.3 | |||||
GO terms in PGGT1B
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0018342 | protein prenylation |
| BP | IBA | GO:0018344 | protein geranylgeranylation |
| BP | IDA | GO:0018344 | protein geranylgeranylation |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
Gene expression in normal tissue: PGGT1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PGGT1B
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PGGT1B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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