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ZBTB16

Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
zinc finger and BTB domain containing 16	MIM:176797	Ensembl:ENSG00000109906	HGNC:HGNC:12930	PA37517	11q23.2

GO terms in ZBTB16

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	ISS	GO:0001823	mesonephros development
BP	IEA	GO:0006351	transcription, DNA-templated
BP	NAS	GO:0006915	apoptotic process
BP	ISS	GO:0007417	central nervous system development
BP	IEA	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0009880	embryonic pattern specification
BP	IEA	GO:0009952	anterior/posterior pattern specification
BP	IEA	GO:0016567	protein ubiquitination
BP	IDA	GO:0030097	hemopoiesis
BP	TAS	GO:0030097	hemopoiesis
BP	TAS	GO:0030099	myeloid cell differentiation
BP	IMP	GO:0032332	positive regulation of chondrocyte differentiation
BP	IEA	GO:0034504	protein localization to nucleus
BP	IEA	GO:0035116	embryonic hindlimb morphogenesis
BP	IEA	GO:0035136	forelimb morphogenesis
BP	IEA	GO:0042733	embryonic digit morphogenesis
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	TAS	GO:0043687	post-translational protein modification
BP	IMP	GO:0045600	positive regulation of fat cell differentiation
BP	ISS	GO:0045638	negative regulation of myeloid cell differentiation
BP	IDA	GO:0045778	positive regulation of ossification
BP	IBA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045892	negative regulation of transcription, DNA-templated
BP	NAS	GO:0045892	negative regulation of transcription, DNA-templated
BP	IBA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048133	male germ-line stem cell asymmetric division
BP	IBA	GO:0048856	anatomical structure development
BP	IEA	GO:0051138	positive regulation of NK T cell differentiation
BP	IDA	GO:0051216	cartilage development
BP	IDA	GO:0061036	positive regulation of cartilage development
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005654	nucleoplasm
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005886	plasma membrane
CC	IDA	GO:0016604	nuclear body
CC	IDA	GO:0016605	PML body
CC	IDA	GO:0016607	nuclear speck
CC	IDA	GO:0017053	transcriptional repressor complex
CC	IMP	GO:0032991	protein-containing complex
MF	IDA	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
MF	IDA	GO:0003677	DNA binding
MF	NAS	GO:0003677	DNA binding
MF	IBA	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008022	protein C-terminus binding
MF	IEA	GO:0019904	protein domain specific binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	IBA	GO:0043565	sequence-specific DNA binding
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: ZBTB16

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZBTB16

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8951664	Neddylation
reactome	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
reactome	R-HSA-983169	Class I MHC mediated antigen processing & presentation
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
kegg	hsa05221	Acute myeloid leukemia - Homo sapiens (human)
wikipathways	WP2858	Ectoderm Differentiation
wikipathways	WP3658	Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways	WP3893	Development and heterogeneity of the ILC family

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD269	Purmorphamine	2
iGMDRD506	Fedratinib	3
iGMDRD872	BRD7137	3
iGMDRD887	Compound 23 citrate	3
iGMDRD188	Piperlongumine	3
iGMDRD64	Parbendazole	2
iGMDRD300	Tozasertib	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD202	Curcumin	3
iGMDRD138	PX 12	2
iGMDRD870	BRD63610	1
iGMDRD187	BRD9876	1
iGMDRD434	BMS-536924	3
iGMDRD289	Parthenolide	2
iGMDRD193	Fqi1	2
iGMDRD61	Kinetin riboside	1
iGMDRD57	Chloropentafluorobenzene	4
iGMDRD446	LY 2183240	2
iGMDRD154	NSC23766	4
iGMDRD945	ML214	2
iGMDRD394	BX-795	1
iGMDRD123	Isoevodiamine	3
iGMDRD579	PF750	2
iGMDRD772	BRD4770	2
iGMDRD151	CHM-1	2
iGMDRD84	Lovastatin acid	2
iGMDRD126	Tipifarnib	2
iGMDRD781	Sirolimus	3
iGMDRD424	Tamatinib	3
iGMDRD70	LHRH analogues or antagonist	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZBTB16

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DATATYPES

CLASSFICATION

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