ZBTB16


Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc finger and BTB domain containing 16MIM:176797Ensembl:ENSG00000109906HGNC:HGNC:12930PA3751711q23.2

GO terms in ZBTB16


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001823mesonephros development
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006915apoptotic process
BPISSGO:0007417central nervous system development
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0009880embryonic pattern specification
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0016567protein ubiquitination
BPIDAGO:0030097hemopoiesis
BPTASGO:0030097hemopoiesis
BPTASGO:0030099myeloid cell differentiation
BPIMPGO:0032332positive regulation of chondrocyte differentiation
BPIEAGO:0034504protein localization to nucleus
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPIEAGO:0035136forelimb morphogenesis
BPIEAGO:0042733embryonic digit morphogenesis
BPIEAGO:0043065positive regulation of apoptotic process
BPTASGO:0043687post-translational protein modification
BPIMPGO:0045600positive regulation of fat cell differentiation
BPISSGO:0045638negative regulation of myeloid cell differentiation
BPIDAGO:0045778positive regulation of ossification
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPNASGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048133male germ-line stem cell asymmetric division
BPIBAGO:0048856anatomical structure development
BPIEAGO:0051138positive regulation of NK T cell differentiation
BPIDAGO:0051216cartilage development
BPIDAGO:0061036positive regulation of cartilage development
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIDAGO:0016604nuclear body
CCIDAGO:0016605PML body
CCIDAGO:0016607nuclear speck
CCIDAGO:0017053transcriptional repressor complex
CCIMPGO:0032991protein-containing complex
MFIDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001206transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIDAGO:0003677DNA binding
MFNASGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIEAGO:0019904protein domain specific binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIBAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ZBTB16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZBTB16


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP3893Development and heterogeneity of the ILC family

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD269Purmorphamine2
iGMDRD506Fedratinib3
iGMDRD872BRD71373
iGMDRD887Compound 23 citrate3
iGMDRD188Piperlongumine3
iGMDRD64Parbendazole2
iGMDRD300Tozasertib2
iGMDRD5Tyrphostin AG 14782
iGMDRD202Curcumin3
iGMDRD138PX 122
iGMDRD870BRD636101
iGMDRD187BRD98761
iGMDRD434BMS-5369243
iGMDRD289Parthenolide2
iGMDRD193Fqi12
iGMDRD61Kinetin riboside1
iGMDRD57Chloropentafluorobenzene4
iGMDRD446LY 21832402
iGMDRD154NSC237664
iGMDRD945ML2142
iGMDRD394BX-7951
iGMDRD123Isoevodiamine3
iGMDRD579PF7502
iGMDRD772BRD47702
iGMDRD151CHM-12
iGMDRD84Lovastatin acid2
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus3
iGMDRD424Tamatinib3
iGMDRD70LHRH analogues or antagonist1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZBTB16

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