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ZBTB16

Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namezinc finger and BTB domain containing 16 OMIM IDMIM:176797 Ensembl IDEnsembl:ENSG00000109906 HGNC IDHGNC:HGNC:12930 PHARMGKB IDPA37517 Map Location11q23.2

GO terms in ZBTB16

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	ISS	GO:0001823	mesonephros development
BP	IEA	GO:0006351	transcription, DNA-templated
BP	NAS	GO:0006915	apoptotic process
BP	ISS	GO:0007417	central nervous system development
BP	IEA	GO:0008285	negative regulation of cell proliferation

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Gene expression in normal tissue: ZBTB16

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZBTB16

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8951664	Neddylation
reactome	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD269	Purmorphamine	2
iGMDRD506	Fedratinib	3
iGMDRD872	BRD7137	3
iGMDRD887	Compound 23 citrate	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZBTB16

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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