ICAM1

Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameintercellular adhesion molecule 1
OMIM IDMIM:147840
Ensembl IDEnsembl:ENSG00000090339
HGNC IDHGNC:HGNC:5344
PHARMGKB IDPA29592
Map Location19p13.2

GO terms in ICAM1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001618 virus receptor activity
MF TAS GO:0004888 transmembrane signaling receptor activity
MF IBA GO:0005178 integrin binding
MF IDA GO:0005178 integrin binding
MF IPI GO:0005178 integrin binding
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: ICAM1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 58BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 5

Gene-drug pathway distribution

undefined13Apoptosis regulation2Biosynthesis of secondary metabolites2WNT signaling1Mitosis1Chromatin other1

Pathways in ICAM1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-168256 Immune System
reactome R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactome R-HSA-216083 Integrin cell surface interactions
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD300 Tozasertib 1
iGMDRD246 NPC26 4
iGMDRD147 Prima-1 1
iGMDRD23 Gossypol 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ICAM1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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