ICAM1
Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| intercellular adhesion molecule 1 | MIM:147840 | Ensembl:ENSG00000090339 | HGNC:HGNC:5344 | PA29592 | 19p13.2 |
GO terms in ICAM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005178 | integrin binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| BP | IEA | GO:0001541 | ovarian follicle development |
| BP | TAS | GO:0001910 | regulation of leukocyte mediated cytotoxicity |
| BP | IEA | GO:0001975 | response to amphetamine |
| BP | IMP | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| BP | IEA | GO:0002438 | acute inflammatory response to antigenic stimulus |
| BP | IEA | GO:0002457 | T cell antigen processing and presentation |
| BP | IMP | GO:0002693 | positive regulation of cellular extravasation |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IMP | GO:0007159 | leukocyte cell-cell adhesion |
| BP | IEA | GO:0007569 | cell aging |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | IEA | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0010212 | response to ionizing radiation |
| BP | IEA | GO:0010477 | response to sulfur dioxide |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEP | GO:0022614 | membrane to membrane docking |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IEA | GO:0031669 | cellular response to nutrient levels |
| BP | IEA | GO:0032868 | response to insulin |
| BP | IEA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEA | GO:0034698 | response to gonadotropin |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0044406 | adhesion of symbiont to host |
| BP | IEA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0045907 | positive regulation of vasoconstriction |
| BP | IEA | GO:0046688 | response to copper ion |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0046813 | receptor-mediated virion attachment to host cell |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IEP | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051926 | negative regulation of calcium ion transport |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IGI | GO:0061028 | establishment of endothelial barrier |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071312 | cellular response to alkaloid |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071347 | cellular response to interleukin-1 |
| BP | IEA | GO:0071354 | cellular response to interleukin-6 |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:0072683 | T cell extravasation |
| BP | IEA | GO:0090557 | establishment of endothelial intestinal barrier |
| BP | IEA | GO:0097368 | establishment of Sertoli cell barrier |
| BP | IEA | GO:1900027 | regulation of ruffle assembly |
| BP | IDA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| BP | IDA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IEA | GO:0001772 | immunological synapse |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ICAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ICAM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | integrin2_pathway | Beta2 integrin cell surface interactions |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD84 | Lovastatin acid | 5 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD772 | BRD4770 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ICAM1
CLASSFICATION
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