Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

intercellular adhesion molecule 1MIM:147840Ensembl:ENSG00000090339HGNC:HGNC:5344PA2959219p13.2

GO terms in ICAM1

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFTASGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005178integrin binding
MFIDAGO:0005178integrin binding
MFIPIGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFTASGO:0038023signaling receptor activity
BPIEAGO:0001541ovarian follicle development
BPTASGO:0001910regulation of leukocyte mediated cytotoxicity
BPIEAGO:0001975response to amphetamine
BPIMPGO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
BPIEAGO:0002438acute inflammatory response to antigenic stimulus
BPIEAGO:0002457T cell antigen processing and presentation
BPIMPGO:0002693positive regulation of cellular extravasation
BPIBAGO:0007155cell adhesion
BPIDAGO:0007155cell adhesion
BPTASGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BPIMPGO:0007159leukocyte cell-cell adhesion
BPIEAGO:0007569cell aging
BPIEAGO:0007605sensory perception of sound
BPIEAGO:0008360regulation of cell shape
BPIEAGO:0010212response to ionizing radiation
BPIEAGO:0010477response to sulfur dioxide
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEPGO:0022614membrane to membrane docking
BPTASGO:0030198extracellular matrix organization
BPIEAGO:0030838positive regulation of actin filament polymerization
BPIEAGO:0031669cellular response to nutrient levels
BPIEAGO:0032868response to insulin
BPIEAGO:0033627cell adhesion mediated by integrin
BPIEAGO:0034698response to gonadotropin
BPIEAGO:0043200response to amino acid
BPIEAGO:0043547positive regulation of GTPase activity
BPIDAGO:0044406adhesion of symbiont to host
BPIEAGO:0045429positive regulation of nitric oxide biosynthetic process
BPIEAGO:0045471response to ethanol
BPIEAGO:0045907positive regulation of vasoconstriction
BPIEAGO:0046688response to copper ion
BPIEAGO:0046718viral entry into host cell
BPIDAGO:0046813receptor-mediated virion attachment to host cell
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPTASGO:0050776regulation of immune response
BPIEPGO:0050900leukocyte migration
BPIEAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051926negative regulation of calcium ion transport
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPIGIGO:0061028establishment of endothelial barrier
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:0071312cellular response to alkaloid
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0071347cellular response to interleukin-1
BPIEAGO:0071354cellular response to interleukin-6
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0071549cellular response to dexamethasone stimulus
BPIEAGO:0072683T cell extravasation
BPIEAGO:0090557establishment of endothelial intestinal barrier
BPIEAGO:0097368establishment of Sertoli cell barrier
BPIEAGO:1900027regulation of ruffle assembly
BPIDAGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:1904996positive regulation of leukocyte adhesion to vascular endothelial cell
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPIDAGO:2000352negative regulation of endothelial cell apoptotic process
CCIEAGO:0001772immunological synapse
CCIDAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0009897external side of plasma membrane
CCHDAGO:0009986cell surface
CCIEAGO:0045121membrane raft
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070062extracellular exosome

Gene expression in normal tissue: ICAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ICAM1

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP176Folate Metabolism
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2806Human Complement System
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP619Type II interferon signaling (IFNG)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtxa2pathwayThromboxane A2 receptor signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD220fumonisin B13
iGMDRD297Austocystin D5
iGMDRD84Lovastatin acid5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ICAM1