RUNX2


Summary: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
runt related transcription factor 2MIM:600211Ensembl:ENSG00000124813HGNC:HGNC:10472PA348856p21.1

GO terms in RUNX2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0001503ossification
BPIEPGO:0001649osteoblast differentiation
BPTASGO:0001649osteoblast differentiation
BPIEAGO:0001958endochondral ossification
BPIEAGO:0002051osteoblast fate commitment
BPIEAGO:0002063chondrocyte development
BPIEAGO:0002076osteoblast development
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0008284positive regulation of cell proliferation
BPIBAGO:0030097hemopoiesis
BPIBAGO:0030182neuron differentiation
BPIEAGO:0030217T cell differentiation
BPISSGO:0030509BMP signaling pathway
BPIEAGO:0032332positive regulation of chondrocyte differentiation
BPIEAGO:0035115embryonic forelimb morphogenesis
BPIEAGO:0040036regulation of fibroblast growth factor receptor signaling pathway
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0042487regulation of odontogenesis of dentin-containing tooth
BPIBAGO:0045595regulation of cell differentiation
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIEAGO:0045879negative regulation of smoothened signaling pathway
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048469cell maturation
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPIEAGO:0048863stem cell differentiation
BPISSGO:0071773cellular response to BMP stimulus
BPISSGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
CCISSGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005667transcription factor complex
CCTASGO:0005829cytosol
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0003682chromatin binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0043425bHLH transcription factor binding
MFIEAGO:0070491repressing transcription factor binding

Gene expression in normal tissue: RUNX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RUNX2


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1425Bone Morphogenic Protein (BMP) Signalling and Regulation
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP3859TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP560TGF-beta Receptor Signaling
pidfgf_pathwayFGF signaling pathway
pidhes_heypathwayNotch-mediated HES/HEY network
pidrb_1pathwayRegulation of retinoblastoma protein
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_LeptinLeptin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941284RUNX2 regulates chondrocyte maturation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-8941332RUNX2 regulates genes involved in cell migration
reactomeR-HSA-8941332RUNX2 regulates genes involved in cell migration
reactomeR-HSA-8941333RUNX2 regulates genes involved in differentiation of myeloid cells

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD144NSC953972
iGMDRD126Tipifarnib2
iGMDRD387CHIR-990213
iGMDRD280CYTOCHALASIN B3
iGMDRD341Triacsin c3
iGMDRD57Chloropentafluorobenzene2
iGMDRD434BMS-5369243
iGMDRD77Itraconazole2
iGMDRD137Indisulam3
iGMDRD271Brefeldin A3
iGMDRD202Curcumin6
iGMDRD5Tyrphostin AG 14783
iGMDRD255SB2250023
iGMDRD300Tozasertib2
iGMDRD524ISX-91
iGMDRD399Selumetinib3
iGMDRD871BRD63683
iGMDRD398Sepantronium5
iGMDRD780PP-302
iGMDRD329Merck606
iGMDRD506Fedratinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RUNX2

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