RUNX1T1
Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RUNX1 translocation partner 1 | MIM:133435 | Ensembl:ENSG00000079102 | HGNC:HGNC:1535 | PA26111 | 8q21.3 |
GO terms in RUNX1T1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0006091 | generation of precursor metabolites and energy |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016363 | nuclear matrix |
Gene expression in normal tissue: RUNX1T1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RUNX1T1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD494 | Neopeltolide | 6 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD49 | Mitomycin | 2 |
| iGMDRD314 | Tanespimycin | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RUNX1T1
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