ADAM10

Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameADAM metallopeptidase domain 10
OMIM IDMIM:602192
Ensembl IDEnsembl:ENSG00000137845
HGNC IDHGNC:HGNC:188
PHARMGKB IDPA24505
Map Location15q21.3

GO terms in ADAM10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004175 endopeptidase activity
MF IMP GO:0004222 metalloendopeptidase activity
MF NAS GO:0004222 metalloendopeptidase activity
MF TAS GO:0004222 metalloendopeptidase activity
MF NAS GO:0005102 signaling receptor binding
MF NAS GO:0005178 integrin binding
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Gene expression in normal tissue: ADAM10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined9Apoptosis regulation1WNT signaling1Other, kinases1

Pathways in ADAM10


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1474244 Extracellular matrix organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD494 Neopeltolide 2
iGMDRD387 CHIR-99021 3
iGMDRD330 BRD4132 2
iGMDRD268 Cerulenin 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAM10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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