MLF1
Summary: This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601402 Ensembl IDEnsembl:ENSG00000178053 HGNC IDHGNC:HGNC:7125 PHARMGKB IDPA30843 Map Location3q25.32 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in MLF1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003677 | DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019904 | protein domain specific binding |
| BP | ISS | GO:0002318 | myeloid progenitor cell differentiation |
| BP | ISS | GO:0006351 | transcription, DNA-templated |
Gene expression in normal tissue: MLF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MLF1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MLF1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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