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MLF1

Summary: This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
myeloid leukemia factor 1	MIM:601402	Ensembl:ENSG00000178053	HGNC:HGNC:7125	PA30843	3q25.32

Gene Categories:

TUMOR SUPPRESSOR

GO terms in MLF1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0003677	DNA binding
MF	ISS	GO:0003677	DNA binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0019904	protein domain specific binding
BP	ISS	GO:0002318	myeloid progenitor cell differentiation
BP	ISS	GO:0006351	transcription, DNA-templated
BP	IBA	GO:0006355	regulation of transcription, DNA-templated
BP	IDA	GO:0007050	cell cycle arrest
CC	HDA	GO:0005634	nucleus
CC	IBA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	ISS	GO:0005737	cytoplasm

Gene expression in normal tissue: MLF1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MLF1

Database	Pathway ID	Pathway Des.
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD387	CHIR-99021	3
iGMDRD506	Fedratinib	1
iGMDRD398	Sepantronium	3
iGMDRD434	BMS-536924	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MLF1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.