CYP1A2


Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cytochrome P450 family 1 subfamily A member 2MIM:124060Ensembl:ENSG00000140505HGNC:HGNC:2596PA2709315q24.1

GO terms in CYP1A2


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0006706steroid catabolic process
BPIEAGO:0006778porphyrin-containing compound metabolic process
BPTASGO:0006805xenobiotic metabolic process
BPIDAGO:0009403toxin biosynthetic process
BPIEAGO:0009791post-embryonic development
BPIDAGO:0009820alkaloid metabolic process
BPIEAGO:0010468regulation of gene expression
BPIDAGO:0016098monoterpenoid metabolic process
BPIDAGO:0017144drug metabolic process
BPIEAGO:0018894dibenzo-p-dioxin metabolic process
BPTASGO:0019373epoxygenase P450 pathway
BPIEAGO:0022900electron transport chain
BPIEAGO:0030324lung development
BPTASGO:0032259methylation
BPIEAGO:0032355response to estradiol
BPIEAGO:0032496response to lipopolysaccharide
BPIDAGO:0032787monocarboxylic acid metabolic process
BPIEAGO:0035902response to immobilization stress
BPIMPGO:0042737drug catabolic process
BPIDAGO:0042738exogenous drug catabolic process
BPTASGO:0042759long-chain fatty acid biosynthetic process
BPIEAGO:0045333cellular respiration
BPIDAGO:0046483heterocycle metabolic process
BPIEAGO:0050665hydrogen peroxide biosynthetic process
BPIDAGO:0055114oxidation-reduction process
BPIDAGO:0070989oxidative demethylation
BPIEAGO:0071276cellular response to cadmium ion
BPIEAGO:0071280cellular response to copper ion
BPIDAGO:0071615oxidative deethylation
BPTASGO:0097267omega-hydroxylase P450 pathway
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0031090organelle membrane
CCIBAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0043231intracellular membrane-bounded organelle
MFIBAGO:0004497monooxygenase activity
MFIDAGO:0004497monooxygenase activity
MFTASGO:0004497monooxygenase activity
MFIEAGO:0005506iron ion binding
MFTASGO:0009055electron transfer activity
MFIDAGO:0016491oxidoreductase activity
MFIMPGO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
MFIPIGO:0019899enzyme binding
MFIDAGO:0020037heme binding
MFIDAGO:0032451demethylase activity
MFIDAGO:0034875caffeine oxidase activity
MFIEAGO:0070330aromatase activity

Gene expression in normal tissue: CYP1A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP1A2


DatabasePathway IDPathway Des.
biocartaacetaminophenpathwaymechanism of acetaminophen activity and toxicity
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-156581Methylation
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211957Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
reactomeR-HSA-211981Xenobiotics
reactomeR-HSA-2142670Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
reactomeR-HSA-2142753Arachidonic acid metabolism
reactomeR-HSA-2142816Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
reactomeR-HSA-5423646Aflatoxin activation and detoxification
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8978868Fatty acid metabolism
reactomeR-HSA-9018677Biosynthesis of DHA-derived SPMs
reactomeR-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)
reactomeR-HSA-9018681Biosynthesis of protectins
reactomeR-HSA-9018682Biosynthesis of maresins
reactomeR-HSA-9027307Biosynthesis of maresin-like SPMs
wikipathwaysWP206Fatty Acid Omega Oxidation
wikipathwaysWP2542Sulindac Metabolic Pathway
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2646Lidocaine metabolism
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2881Estrogen Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3633Caffeine and Theobromine metabolism
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP43Oxidation by Cytochrome P450
wikipathwaysWP465Tryptophan metabolism
wikipathwaysWP691Tamoxifen metabolism
wikipathwaysWP694Arylamine metabolism
wikipathwaysWP697Estrogen metabolism
wikipathwaysWP699Aflatoxin B1 metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II
smpdbSMP00028Caffeine Metabolism
smpdbSMP00260Clopidogrel Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00398Lidocaine (Local Anaesthetic) Action Pathway
smpdbSMP00422Imipramine Action Pathway
smpdbSMP00610Clopidogrel Metabolism Pathway
smpdbSMP00620Lidocaine (Local Anaesthetic) Metabolism Pathway
smpdbSMP00625Imipramine Metabolism Pathway
smpdbSMP00639Clomipramine Metabolism Pathway
smpdbSMP00640Acetaminophen Metabolism Pathway
smpdbSMP00641Doxepin Metabolism Pathway
pharmgkbPA145011113Warfarin Pathway, Pharmacokinetics
pharmgkbPA145011115Phenytoin Pathway, Pharmacokinetics
pharmgkbPA145011118Estrogen Metabolism Pathway
pharmgkbPA145011119Tamoxifen Pathway, Pharmacokinetics
pharmgkbPA154424674Clopidogrel Pathway, Pharmacokinetics
pharmgkbPA154426903Erlotinib Pathway, Pharmacokinetics
pharmgkbPA162359940Imipramine/Desipramine Pathway, Pharmacokinetics
pharmgkbPA164713427Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA165111375Benzodiazepine Pathway, Pharmacokinetics
pharmgkbPA165817070Carbamazepine Pathway, Pharmacokinetics
pharmgkbPA165884757Caffeine Pathway, Pharmacokinetics
pharmgkbPA165958541Theophylline Pathway, Pharmacokinetics
pharmgkbPA165960076Clomipramine Pathway, Pharmacokinetics
pharmgkbPA165981686Doxepin Pathway, Pharmacokinetics
pharmgkbPA165986194Pathway_PA165986194 -need delete
pharmgkbPA165986279Acetaminophen Pathway, Pharmacokinetics
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa00232Caffeine metabolism - Homo sapiens (human)
kegghsa00380Tryptophan metabolism - Homo sapiens (human)
kegghsa00591Linoleic acid metabolism - Homo sapiens (human)
kegghsa00830Retinol metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
humancycPWY-6398melatonin degradation I
humancycPWY-6402superpathway of melatonin degradation
humancycPWY66-401superpathway of tryptophan utilization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib3
iGMDRD387CHIR-990213
iGMDRD579PF7502
iGMDRD772BRD47706
iGMDRD427ABT7373
iGMDRD484Pluripotin3
iGMDRD201SKI II3
iGMDRD280CYTOCHALASIN B3
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080416
iGMDRD380Pifithrin-alpha6
iGMDRD513BML-2591
iGMDRD247Blebbistatin5
iGMDRD8024-methylfasudil4
iGMDRD318PAC-19
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD294Batimastat1
iGMDRD577BIX012946
iGMDRD888Compound 443
iGMDRD224Necrostatin-13
iGMDRD780PP-301
iGMDRD690PRIMA-1MET6
iGMDRD60Quinoclamine6
iGMDRD23Gossypol3
iGMDRD268Cerulenin6
iGMDRD451Serdemetan3
iGMDRD607Ubistatin B6
iGMDRD148Pifithrin-mu6
iGMDRD701NVP-AUY9223
iGMDRD219Bax channel blocker3
iGMDRD137Indisulam3
iGMDRD213SMR0000686506
iGMDRD871BRD63686
iGMDRD329Merck606
iGMDRD147Prima-13
iGMDRD82Quiflapon3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP1A2

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