CYP1A2
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:124060 Ensembl IDEnsembl:ENSG00000140505 HGNC IDHGNC:HGNC:2596 PHARMGKB IDPA27093 Map Location15q24.1 | |||||
GO terms in CYP1A2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0006706 | steroid catabolic process |
| BP | IEA | GO:0006778 | porphyrin-containing compound metabolic process |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0009403 | toxin biosynthetic process |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IDA | GO:0009820 | alkaloid metabolic process |
Gene expression in normal tissue: CYP1A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP1A2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | acetaminophenpathway | mechanism of acetaminophen activity and toxicity |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156581 | Methylation |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP1A2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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