TLK2
Summary: This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tousled like kinase 2 | MIM:608439 | Ensembl:ENSG00000146872 | HGNC:HGNC:11842 | PA36544 | 17q23.2 |
GO terms in TLK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005882 | intermediate filament |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IDA | GO:0001672 | regulation of chromatin assembly or disassembly |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IMP | GO:0007059 | chromosome segregation |
| BP | NAS | GO:0010507 | negative regulation of autophagy |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: TLK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP707 | DNA Damage Response |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLK2
CLASSFICATION
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