GOPC


Summary: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in GOPC


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Term Type
Evidence Type
GO Term ID
GO Des.
BP NAS GO:0006888 ER to Golgi vesicle-mediated transport
BP NAS GO:0006893 Golgi to plasma membrane transport
BP IMP GO:0010360 negative regulation of anion channel activity
BP IEA GO:0015031 protein transport
BP IMP GO:0043004 cytoplasmic sequestering of CFTR protein
BP NAS GO:0045176 apical protein localization
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Gene expression in normal tissue: GOPC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GOPC


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-195258 RHO GTPase Effectors
reactome R-HSA-5627083 RHO GTPases regulate CFTR trafficking
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 1
iGMDRD424 Tamatinib 1
iGMDRD387 CHIR-99021 1
iGMDRD584 VER 155008 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GOPC

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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