GOPC


Summary: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
golgi associated PDZ and coiled-coil motif containingMIM:606845Ensembl:ENSG00000047932HGNC:HGNC:17643PA1349049446q22.1

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in GOPC


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0006888ER to Golgi vesicle-mediated transport
BPNASGO:0006893Golgi to plasma membrane transport
BPIMPGO:0010360negative regulation of anion channel activity
BPIEAGO:0015031protein transport
BPIMPGO:0043004cytoplasmic sequestering of CFTR protein
BPNASGO:0045176apical protein localization
BPIPIGO:0051260protein homooligomerization
BPIMPGO:2000009negative regulation of protein localization to cell surface
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005737cytoplasm
CCTASGO:0005765lysosomal membrane
CCIDAGO:0005794Golgi apparatus
CCNASGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0014069postsynaptic density
CCIDAGO:0016020membrane
CCIEAGO:0030054cell junction
CCIDAGO:0030140trans-Golgi network transport vesicle
CCNASGO:0030140trans-Golgi network transport vesicle
CCIEAGO:0030425dendrite
CCTASGO:0030660Golgi-associated vesicle membrane
CCIDAGO:0032991protein-containing complex
CCIEAGO:0045211postsynaptic membrane
MFIPIGO:0005515protein binding
MFIPIGO:0044325ion channel binding

Gene expression in normal tissue: GOPC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GOPC


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-5627083RHO GTPases regulate CFTR trafficking

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369241
iGMDRD424Tamatinib1
iGMDRD387CHIR-990211
iGMDRD584VER 1550081
iGMDRD121GMX17783
iGMDRD297Austocystin D3
iGMDRD61Kinetin riboside6
iGMDRD341Triacsin c3
iGMDRD100Zebularine3
iGMDRD871BRD63683
iGMDRD446LY 21832403
iGMDRD399Selumetinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GOPC

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