GOPC
Summary: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| golgi associated PDZ and coiled-coil motif containing | MIM:606845 | Ensembl:ENSG00000047932 | HGNC:HGNC:17643 | PA134904944 | 6q22.1 |
GO terms in GOPC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | NAS | GO:0006893 | Golgi to plasma membrane transport |
| BP | IMP | GO:0010360 | negative regulation of anion channel activity |
| BP | IEA | GO:0015031 | protein transport |
| BP | IMP | GO:0043004 | cytoplasmic sequestering of CFTR protein |
| BP | NAS | GO:0045176 | apical protein localization |
| BP | IPI | GO:0051260 | protein homooligomerization |
| BP | IMP | GO:2000009 | negative regulation of protein localization to cell surface |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0030140 | trans-Golgi network transport vesicle |
| CC | NAS | GO:0030140 | trans-Golgi network transport vesicle |
| CC | IEA | GO:0030425 | dendrite |
| CC | TAS | GO:0030660 | Golgi-associated vesicle membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0044325 | ion channel binding |
Gene expression in normal tissue: GOPC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GOPC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5627083 | RHO GTPases regulate CFTR trafficking |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD399 | Selumetinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GOPC
CLASSFICATION
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