GOPC
Summary: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:606845 Ensembl IDEnsembl:ENSG00000047932 HGNC IDHGNC:HGNC:17643 PHARMGKB IDPA134904944 Map Location6q22.1 |
GO terms in GOPC
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | NAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
BP | NAS | GO:0006893 | Golgi to plasma membrane transport |
BP | IMP | GO:0010360 | negative regulation of anion channel activity |
BP | IEA | GO:0015031 | protein transport |
BP | IMP | GO:0043004 | cytoplasmic sequestering of CFTR protein |
BP | NAS | GO:0045176 | apical protein localization |
Gene expression in normal tissue: GOPC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GOPC
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-195258 | RHO GTPase Effectors |
reactome | R-HSA-5627083 | RHO GTPases regulate CFTR trafficking |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in GOPC
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |