ABCC3

Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameATP binding cassette subfamily C member 3
OMIM IDMIM:604323
Ensembl IDEnsembl:ENSG00000108846
HGNC IDHGNC:HGNC:54
PHARMGKB IDPA376
Map Location17q21.33

GO terms in ABCC3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005524 ATP binding
MF TAS GO:0008514 organic anion transmembrane transporter activity
MF TAS GO:0015432 bile acid-exporting ATPase activity
MF IBA GO:0042626 ATPase activity, coupled to transmembrane movement of substances
MF TAS GO:0042626 ATPase activity, coupled to transmembrane movement of substances
MF TAS GO:0043225 ATPase-coupled anion transmembrane transporter activity
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Gene expression in normal tissue: ABCC3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 19LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 30undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 29undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 20UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 4BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2

Gene-drug pathway distribution

undefined25Metabolic pathways2Protein stability and degradation2Apoptosis regulation1One carbon pool by folate1WNT signaling1Longevity regulating pathway1Cell cycle1Mitosis1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in ABCC3


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Database
Pathway ID
Pathway Des.
pharmgkb PA146123006 Codeine and Morphine Pathway, Pharmacokinetics
pharmgkb PA150653776 Fluoropyrimidine Pathway, Pharmacokinetics
pharmgkb PA150981002 Vinka Alkaloid Pathway, Pharmacokinetics
pharmgkb PA165816349 Methotrexate Pathway, Pharmacokinetics
pharmgkb PA165860384 Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkb PA2025 Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD158 NSC141540 3
iGMDRD448 Monomethyl auristatin E 1
iGMDRD137 Indisulam 3
iGMDRD202 Curcumin 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCC3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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