ABCC3
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily C member 3 | MIM:604323 | Ensembl:ENSG00000108846 | HGNC:HGNC:54 | PA376 | 17q21.33 |
GO terms in ABCC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008514 | organic anion transmembrane transporter activity |
| MF | TAS | GO:0015432 | bile acid-exporting ATPase activity |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0043225 | ATPase-coupled anion transmembrane transporter activity |
| CC | IBA | GO:0005774 | vacuolar membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | TAS | GO:0016020 | membrane |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | ISS | GO:0015722 | canalicular bile acid transport |
| BP | IBA | GO:0055085 | transmembrane transport |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IEA | GO:0099133 | ATP hydrolysis coupled anion transmembrane transport |
Gene expression in normal tissue: ABCC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA146123006 | Codeine and Morphine Pathway, Pharmacokinetics |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2025 | Etoposide Pathway, Pharmacokinetics/Pharmacodynamics |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP4010 | Liver steatosis AOP |
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00437 | Vincristine Action Pathway |
| smpdb | SMP00438 | Vindesine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| biocarta | mrppathway | multi-drug resistance factors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD448 | Monomethyl auristatin E | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD299 | ICL 670 | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCC3
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