AURKC
Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aurora kinase C | MIM:603495 | Ensembl:ENSG00000105146 | HGNC:HGNC:11391 | PA36200 | 19q13.43 |
GO terms in AURKC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000780 | condensed nuclear chromosome, centromeric region |
| CC | IDA | GO:0000793 | condensed chromosome |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005819 | spindle |
| CC | IBA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0030496 | midbody |
| CC | TAS | GO:0030496 | midbody |
| CC | IBA | GO:0031616 | spindle pole centrosome |
| CC | IBA | GO:0032133 | chromosome passenger complex |
| CC | TAS | GO:0032133 | chromosome passenger complex |
| CC | IBA | GO:0051233 | spindle midzone |
| CC | IDA | GO:0051233 | spindle midzone |
| BP | IEA | GO:0000910 | cytokinesis |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007052 | mitotic spindle organization |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0008608 | attachment of spindle microtubules to kinetochore |
| BP | TAS | GO:0016570 | histone modification |
| BP | IBA | GO:0032465 | regulation of cytokinesis |
| BP | TAS | GO:0032467 | positive regulation of cytokinesis |
| BP | IEA | GO:0035404 | histone-serine phosphorylation |
| BP | IEA | GO:0048599 | oocyte development |
| BP | TAS | GO:0051256 | mitotic spindle midzone assembly |
| BP | IEA | GO:0051321 | meiotic cell cycle |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0035174 | histone serine kinase activity |
Gene expression in normal tissue: AURKC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AURKC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_b_pathway | Aurora B signaling |
| pid | aurora_c_pathway | Aurora C signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD414 | MST-312 | 9 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD705 | Nakiterpiosin | 9 |
| iGMDRD484 | Pluripotin | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AURKC
CLASSFICATION
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