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AURKC

Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameaurora kinase C OMIM IDMIM:603495 Ensembl IDEnsembl:ENSG00000105146 HGNC IDHGNC:HGNC:11391 PHARMGKB IDPA36200 Map Location19q13.43

Gene Categories:

DRUGGABLE GENOME HISTONE MODIFICATION SERINE THREONINE KINASE TUMOR SUPPRESSOR KINASE

GO terms in AURKC

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0000780	condensed nuclear chromosome, centromeric region
CC	IDA	GO:0000793	condensed chromosome
CC	IEA	GO:0005737	cytoplasm
CC	TAS	GO:0005819	spindle
CC	IBA	GO:0005876	spindle microtubule
CC	IDA	GO:0030496	midbody

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Gene expression in normal tissue: AURKC

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AURKC

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Database	Pathway ID	Pathway Des.
pid	aurora_b_pathway	Aurora B signaling
pid	aurora_c_pathway	Aurora C signaling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	3
iGMDRD414	MST-312	9
iGMDRD286	Nsc 632839	6
iGMDRD351	GW843682X	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AURKC

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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