AKAP12
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604698 Ensembl IDEnsembl:ENSG00000131016 HGNC IDHGNC:HGNC:370 PHARMGKB IDPA24664 Map Location6q25.1 | |||||
GO terms in AKAP12
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006605 | protein targeting |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0010738 | regulation of protein kinase A signaling |
| BP | IEA | GO:0010739 | positive regulation of protein kinase A signaling |
| BP | IEA | GO:0090036 | regulation of protein kinase C signaling |
Gene expression in normal tissue: AKAP12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKAP12
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP35 | G Protein Signaling Pathways |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKAP12
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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