GNRH1
Summary: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:152760 Ensembl IDEnsembl:ENSG00000147437 HGNC IDHGNC:HGNC:4419 PHARMGKB IDPA28798 Map Location8p21.2 | |||||
GO terms in GNRH1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005798 | Golgi-associated vesicle |
| CC | IEA | GO:0030425 | dendrite |
Gene expression in normal tissue: GNRH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GNRH1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| wikipathways | WP4194 | Hormonal control of Pubertal Growth Spurt |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GNRH1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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