GNRH1


Summary: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
gonadotropin releasing hormone 1MIM:152760Ensembl:ENSG00000147437HGNC:HGNC:4419PA287988p21.2

GO terms in GNRH1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0005615extracellular space
CCIEAGO:0005739mitochondrion
CCIEAGO:0005798Golgi-associated vesicle
CCIEAGO:0030425dendrite
CCIEAGO:0043204perikaryon
CCIEAGO:0043679axon terminus
CCIEAGO:0098556cytoplasmic side of rough endoplasmic reticulum membrane
CCIEAGO:1990008neurosecretory vesicle
BPIBAGO:0000003reproduction
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPTASGO:0007275multicellular organism development
BPIEAGO:0007565female pregnancy
BPIEAGO:0007568aging
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0010468regulation of gene expression
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0030238male sex determination
BPIEAGO:0031960response to corticosteroid
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0033087negative regulation of immature T cell proliferation
BPIEAGO:0033574response to testosterone
BPIEAGO:0034695response to prostaglandin E
BPIEAGO:0035864response to potassium ion
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0044849estrous cycle
BPIEAGO:0045471response to ethanol
BPIEAGO:1990637response to prolactin
BPIEAGO:2000354regulation of ovarian follicle development
BPIEAGO:2001223negative regulation of neuron migration
MFTASGO:0005179hormone activity
MFIBAGO:0005183gonadotropin hormone-releasing hormone activity
MFIEAGO:0005183gonadotropin hormone-releasing hormone activity
MFIBAGO:0031530gonadotropin-releasing hormone receptor binding

Gene expression in normal tissue: GNRH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GNRH1


DatabasePathway IDPathway Des.
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
pidar_nongenomic_pathwayNongenotropic Androgen signaling
wikipathwaysWP4194Hormonal control of Pubertal Growth Spurt
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375281Hormone ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD398Sepantronium3
iGMDRD329Merck603
iGMDRD387CHIR-990213

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GNRH1

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