EDNRA
Summary: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endothelin receptor type A | MIM:131243 | Ensembl:ENSG00000151617 | HGNC:HGNC:3179 | PA27617 | 4q31.22-q31.23 |
GO terms in EDNRA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | NAS | GO:0004962 | endothelin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| BP | IEA | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | NAS | GO:0006939 | smooth muscle contraction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | NAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007190 | activation of adenylate cyclase activity |
| BP | IEA | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | TAS | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IEA | GO:0007507 | heart development |
| BP | ISS | GO:0007585 | respiratory gaseous exchange |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | NAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0010827 | regulation of glucose transmembrane transport |
| BP | IEA | GO:0014032 | neural crest cell development |
| BP | IMP | GO:0014824 | artery smooth muscle contraction |
| BP | IMP | GO:0042310 | vasoconstriction |
| BP | IEA | GO:0048484 | enteric nervous system development |
| BP | IEA | GO:0060322 | head development |
| BP | IEA | GO:0086100 | endothelin receptor signaling pathway |
| BP | ISS | GO:1904659 | glucose transmembrane transport |
Gene expression in normal tissue: EDNRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EDNRA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pid | endothelinpathway | Endothelins |
| pid | et_egfrpathway | EGFR-dependent Endothelin signaling events |
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP3967 | miR-509-3p alteration of YAP1-ECM axis |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EDNRA
CLASSFICATION
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