EDNRA

Summary: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameendothelin receptor type A
OMIM IDMIM:131243
Ensembl IDEnsembl:ENSG00000151617
HGNC IDHGNC:HGNC:3179
PHARMGKB IDPA27617
Map Location4q31.22-q31.23

GO terms in EDNRA


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004435 phosphatidylinositol phospholipase C activity
MF NAS GO:0004962 endothelin receptor activity
MF IPI GO:0005515 protein binding
CC TAS GO:0005886 plasma membrane
CC TAS GO:0005887 integral component of plasma membrane
BP IEA GO:0001569 branching involved in blood vessel morphogenesis
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Gene expression in normal tissue: EDNRA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 33BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1

Gene-drug pathway distribution

undefined11WNT signaling1Longevity regulating pathway1ERK MAPK signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1PI3K/MTOR signaling1

Pathways in EDNRA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-375276 Peptide ligand-binding receptors
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-416476 G alpha (q) signalling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD6 AM-580 3
iGMDRD105 Triptolide 2
iGMDRD202 Curcumin 2
iGMDRD137 Indisulam 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDNRA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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