PCDH18
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protocadherin 18 | MIM:608287 | Ensembl:ENSG00000189184 | HGNC:HGNC:14268 | PA33002 | 4q28.3 |
GO terms in PCDH18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007267 | cell-cell signaling |
| BP | ISS | GO:0007420 | brain development |
| MF | IEA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: PCDH18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCDH18
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD200 | STF62247 | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCDH18
CLASSFICATION
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