ITGA10

Summary: Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameintegrin subunit alpha 10
OMIM IDMIM:604042
Ensembl IDEnsembl:ENSG00000143127
HGNC IDHGNC:HGNC:6135
PHARMGKB IDPA29936
Map Location1q21.1

Gene Categories:

DRUGGABLE GENOME

GO terms in ITGA10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005518 collagen binding
MF IEA GO:0046872 metal ion binding
MF IMP GO:0098639 collagen binding involved in cell-matrix adhesion
BP IMP GO:0007160 cell-matrix adhesion
BP IMP GO:0007229 integrin-mediated signaling pathway
BP TAS GO:0030198 extracellular matrix organization
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Gene expression in normal tissue: ITGA10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined23PI3K/MTOR signaling3Apoptosis regulation2Cell cycle1Chromatin histone acetylation1WNT signaling1Other, kinases1Longevity regulating pathway1

Pathways in ITGA10


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Database
Pathway ID
Pathway Des.
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
kegg hsa04510 Focal adhesion - Homo sapiens (human)
kegg hsa04512 ECM-receptor interaction - Homo sapiens (human)
kegg hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
kegg hsa05165 Human papillomavirus infection - Homo sapiens (human)
kegg hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 5
iGMDRD730 Kahalalide F 3
iGMDRD188 Piperlongumine 3
iGMDRD562 Navitoclax 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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