ITGA10
Summary: Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 10 | MIM:604042 | Ensembl:ENSG00000143127 | HGNC:HGNC:6135 | PA29936 | 1q21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ITGA10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005518 | collagen binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IMP | GO:0098639 | collagen binding involved in cell-matrix adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IDA | GO:0034680 | integrin alpha10-beta1 complex |
Gene expression in normal tissue: ITGA10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447041 | CHL1 interactions |
| reactome | R-HSA-75892 | Platelet Adhesion to exposed collagen |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 5 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD481 | Dactolisib | 5 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA10
CLASSFICATION
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