IFNG
Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon gamma | MIM:147570 | Ensembl:ENSG00000111537 | HGNC:HGNC:5438 | PA29674 | 12q15 |
GO terms in IFNG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005133 | interferon-gamma receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| BP | IDA | GO:0000060 | protein import into nucleus, translocation |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | IGI | GO:0006915 | apoptotic process |
| BP | IBA | GO:0006959 | humoral immune response |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0009615 | response to virus |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010508 | positive regulation of autophagy |
| BP | HDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IDA | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IDA | GO:0010835 | regulation of protein ADP-ribosylation |
| BP | ISS | GO:0030857 | negative regulation of epithelial cell differentiation |
| BP | IDA | GO:0031334 | positive regulation of protein complex assembly |
| BP | IDA | GO:0032700 | negative regulation of interleukin-17 production |
| BP | IDA | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IDA | GO:0032747 | positive regulation of interleukin-23 production |
| BP | IDA | GO:0032834 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| BP | IDA | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| BP | NAS | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| BP | IDA | GO:0033160 | positive regulation of protein import into nucleus, translocation |
| BP | IDA | GO:0034393 | positive regulation of smooth muscle cell apoptotic process |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IDA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IDA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | TAS | GO:0045589 | regulation of regulatory T cell differentiation |
| BP | IDA | GO:0045672 | positive regulation of osteoclast differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IDA | GO:0050796 | regulation of insulin secretion |
| BP | IDA | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IDA | GO:0051712 | positive regulation of killing of cells of other organism |
| BP | IDA | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway |
| BP | IDA | GO:0060550 | positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity |
| BP | IDA | GO:0060552 | positive regulation of fructose 1,6-bisphosphate metabolic process |
| BP | IDA | GO:0060557 | positive regulation of vitamin D biosynthetic process |
| BP | IDA | GO:0060559 | positive regulation of calcidiol 1-monooxygenase activity |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IDA | GO:0090312 | positive regulation of protein deacetylation |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | HDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | HDA | GO:1903543 | positive regulation of exosomal secretion |
| BP | IDA | GO:1904798 | positive regulation of core promoter binding |
| BP | IDA | GO:2000309 | positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
Gene expression in normal tissue: IFNG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IFNG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03050 | Proteasome - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP183 | Proteasome Degradation |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4079 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP516 | Hypertrophy Model |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | ifngpathway | ifn gamma signaling pathway |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | no2il12pathway | no2-dependent il-12 pathway in nk cells |
| biocarta | tidpathway | chaperones modulate interferon signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD670 | ML 210 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IFNG
CLASSFICATION
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