IFNG

Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterferon gamma
OMIM IDMIM:147570
Ensembl IDEnsembl:ENSG00000111537
HGNC IDHGNC:HGNC:5438
PHARMGKB IDPA29674
Map Location12q15

GO terms in IFNG


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005125 cytokine activity
MF IEA GO:0005133 interferon-gamma receptor binding
MF IPI GO:0005515 protein binding
CC IDA GO:0005576 extracellular region
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
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Gene expression in normal tissue: IFNG

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 54BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16

Gene-drug pathway distribution

undefined18Apoptosis regulation2Longevity regulating pathway1WNT signaling1Biosynthesis of secondary metabolites1p53 pathway1Ferroptosis1

Pathways in IFNG


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Database
Pathway ID
Pathway Des.
kegg hsa03050 Proteasome - Homo sapiens (human)
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04217 Necroptosis - Homo sapiens (human)
kegg hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
kegg hsa04380 Osteoclast differentiation - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD398 Sepantronium 2
iGMDRD888 Compound 44 3
iGMDRD329 Merck60 2
iGMDRD451 Serdemetan 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IFNG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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