Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].

interferon gammaMIM:147570Ensembl:ENSG00000111537HGNC:HGNC:5438PA2967412q15

GO terms in IFNG

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005125cytokine activity
MFIEAGO:0005133interferon-gamma receptor binding
MFIPIGO:0005515protein binding
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
BPIDAGO:0000060protein import into nucleus, translocation
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0002250adaptive immune response
BPIGIGO:0006915apoptotic process
BPIBAGO:0006959humoral immune response
BPIDAGO:0007050cell cycle arrest
BPTASGO:0007166cell surface receptor signaling pathway
BPISSGO:0008284positive regulation of cell proliferation
BPIDAGO:0009615response to virus
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010508positive regulation of autophagy
BPHDAGO:0010628positive regulation of gene expression
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPIDAGO:0010634positive regulation of epithelial cell migration
BPIDAGO:0010835regulation of protein ADP-ribosylation
BPISSGO:0030857negative regulation of epithelial cell differentiation
BPIDAGO:0031334positive regulation of protein complex assembly
BPIDAGO:0032700negative regulation of interleukin-17 production
BPIDAGO:0032735positive regulation of interleukin-12 production
BPIDAGO:0032747positive regulation of interleukin-23 production
BPIDAGO:0032834positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
BPIDAGO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein
BPNASGO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein
BPIDAGO:0033160positive regulation of protein import into nucleus, translocation
BPIDAGO:0034393positive regulation of smooth muscle cell apoptotic process
BPTASGO:0035722interleukin-12-mediated signaling pathway
BPIEAGO:0040008regulation of growth
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIDAGO:0045429positive regulation of nitric oxide biosynthetic process
BPTASGO:0045589regulation of regulatory T cell differentiation
BPIDAGO:0045672positive regulation of osteoclast differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0048662negative regulation of smooth muscle cell proliferation
BPIDAGO:0050796regulation of insulin secretion
BPIDAGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPIEAGO:0051607defense response to virus
BPIDAGO:0051712positive regulation of killing of cells of other organism
BPIDAGO:0060333interferon-gamma-mediated signaling pathway
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPTASGO:0060334regulation of interferon-gamma-mediated signaling pathway
BPIDAGO:0060550positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
BPIDAGO:0060552positive regulation of fructose 1,6-bisphosphate metabolic process
BPIDAGO:0060557positive regulation of vitamin D biosynthetic process
BPIDAGO:0060559positive regulation of calcidiol 1-monooxygenase activity
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
BPIDAGO:0090312positive regulation of protein deacetylation
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPHDAGO:1903078positive regulation of protein localization to plasma membrane
BPHDAGO:1903543positive regulation of exosomal secretion
BPIDAGO:1904798positive regulation of core promoter binding
BPIDAGO:2000309positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Gene expression in normal tissue: IFNG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IFNG

DatabasePathway IDPathway Des.
kegghsa03050Proteasome - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
pidatf2_pathwayATF-2 transcription factor network
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidifngpathwayIFN-gamma pathway
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil23pathwayIL23-mediated signaling events
pidil27pathwayIL27-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidshp2_pathwaySHP2 signaling
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
pidtelomerasepathwayRegulation of Telomerase
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP176Folate Metabolism
wikipathwaysWP183Proteasome Degradation
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3893Development and heterogeneity of the ILC family
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4079RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
wikipathwaysWP4100Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP516Hypertrophy Model
wikipathwaysWP530Cytokines and Inflammatory Response
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP619Type II interferon signaling (IFNG)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
reactomeR-HSA-9020591Interleukin-12 signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-913531Interferon Signaling
biocarta41bbpathwaythe 41bb-dependent immune response
biocartaifngpathwayifn gamma signaling pathway
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartano2il12pathwayno2-dependent il-12 pathway in nk cells
biocartatidpathwaychaperones modulate interferon signaling pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD888Compound 443
iGMDRD138PX 123
iGMDRD639YK 4-2793
iGMDRD446LY 21832401
iGMDRD670ML 2103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IFNG