IL1A


Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 1 alphaMIM:147760Ensembl:ENSG00000115008HGNC:HGNC:5991PA298072q14.1

GO terms in IL1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0005125cytokine activity
MFIDAGO:0005507copper ion binding
MFIPIGO:0005515protein binding
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIMPGO:0005615extracellular space
CCIDAGO:0005829cytosol
BPIEAGO:0001660fever generation
BPIEAGO:0002248connective tissue replacement involved in inflammatory response wound healing
BPTASGO:0006915apoptotic process
BPTASGO:0006954inflammatory response
BPIEAGO:0006955immune response
BPTASGO:0008283cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPISSGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010628positive regulation of gene expression
BPIMPGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0034605cellular response to heat
BPIEAGO:0035234ectopic germ cell programmed cell death
BPIMPGO:0045086positive regulation of interleukin-2 biosynthetic process
BPISSGO:0045766positive regulation of angiogenesis
BPIMPGO:0045840positive regulation of mitotic nuclear division
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046688response to copper ion
BPIMPGO:0050714positive regulation of protein secretion
BPIDAGO:0050715positive regulation of cytokine secretion
BPIEAGO:0051781positive regulation of cell division
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIEAGO:0071639positive regulation of monocyte chemotactic protein-1 production
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:2000391positive regulation of neutrophil extravasation
BPTASGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Gene expression in normal tissue: IL1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1A


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448706Interleukin-1 processing
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9020702Interleukin-1 signaling
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartahsp27pathwaystress induction of hsp regulation
biocartail10pathwayil-10 anti-inflammatory signaling pathway
biocartail1rpathwaysignal transduction through il1r
biocartanfkbpathwaynf-kb signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidil1pathwayIL1-mediated signaling events
netpathPathway_IL1IL1
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3391Senescence-Associated Secretory Phenotype (SASP)
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3656Interleukin-1 Induced Activation of NF-kappa-B
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3877Simplified Depiction of MYD88 Distinct Input-Output Pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP516Hypertrophy Model
wikipathwaysWP530Cytokines and Inflammatory Response
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus3
iGMDRD144NSC953971
iGMDRD387CHIR-990211
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib2
iGMDRD280CYTOCHALASIN B2
iGMDRD61Kinetin riboside2
iGMDRD446LY 21832402
iGMDRD187BRD98762
iGMDRD268Cerulenin1
iGMDRD356PNU-746543
iGMDRD451Serdemetan3
iGMDRD888Compound 443
iGMDRD780PP-303
iGMDRD398Sepantronium2
iGMDRD562Navitoclax2
iGMDRD100Zebularine5
iGMDRD188Piperlongumine5
iGMDRD887Compound 23 citrate2
iGMDRD584VER 1550082
iGMDRD512nutlin 31
iGMDRD48Dexamethasone2
iGMDRD307Manumycin A2
iGMDRD123Isoevodiamine1
iGMDRD314Tanespimycin2
iGMDRD85Ursolic acid3
iGMDRD289Parthenolide2
iGMDRD105Triptolide2
iGMDRD434BMS-5369241
iGMDRD5Tyrphostin AG 14781
iGMDRD121GMX17782
iGMDRD322FK 8662
iGMDRD246NPC261
iGMDRD147Prima-12
iGMDRD662JQ-12
iGMDRD329Merck602

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1A

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