IL1A
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 alpha | MIM:147760 | Ensembl:ENSG00000115008 | HGNC:HGNC:5991 | PA29807 | 2q14.1 |
GO terms in IL1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005507 | copper ion binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IMP | GO:0005615 | extracellular space |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0001660 | fever generation |
| BP | IEA | GO:0002248 | connective tissue replacement involved in inflammatory response wound healing |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IEA | GO:0035234 | ectopic germ cell programmed cell death |
| BP | IMP | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046688 | response to copper ion |
| BP | IMP | GO:0050714 | positive regulation of protein secretion |
| BP | IDA | GO:0050715 | positive regulation of cytokine secretion |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IEA | GO:2000391 | positive regulation of neutrophil extravasation |
| BP | TAS | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Gene expression in normal tissue: IL1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448706 | Interleukin-1 processing |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | il10pathway | il-10 anti-inflammatory signaling pathway |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | il1pathway | IL1-mediated signaling events |
| netpath | Pathway_IL1 | IL1 |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3656 | Interleukin-1 Induced Activation of NF-kappa-B |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP516 | Hypertrophy Model |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1A
CLASSFICATION
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