MMP2
Summary: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 2 | MIM:120360 | Ensembl:ENSG00000087245 | HGNC:HGNC:7166 | PA30877 | 16q12.2 |
GO terms in MMP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | EXP | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001955 | blood vessel maturation |
| BP | IEA | GO:0001957 | intramembranous ossification |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IEP | GO:0035987 | endodermal cell differentiation |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045089 | positive regulation of innate immune response |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0060325 | face morphogenesis |
| BP | IEA | GO:0060346 | bone trabecula formation |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IMP | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030017 | sarcomere |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
Gene expression in normal tissue: MMP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | reckpathway | inhibition of matrix metalloproteinases |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP3307 | MAPK6-MAPK4 signaling |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 4 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD579 | PF750 | 4 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD294 | Batimastat | 4 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD451 | Serdemetan | 6 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD837 | Bevacizumab | 2 |
| iGMDRD100 | Zebularine | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP2
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.