MMP2
Summary: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:120360 Ensembl IDEnsembl:ENSG00000087245 HGNC IDHGNC:HGNC:7166 PHARMGKB IDPA30877 Map Location16q12.2 |
GO terms in MMP2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004222 | metalloendopeptidase activity |
MF | EXP | GO:0004252 | serine-type endopeptidase activity |
MF | TAS | GO:0004252 | serine-type endopeptidase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0008237 | metallopeptidase activity |
MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: MMP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP2
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | reckpathway | inhibition of matrix metalloproteinases |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-1442490 | Collagen degradation |
reactome | R-HSA-1442490 | Collagen degradation |
reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MMP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |