MMP2


Summary: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:120360
PHARMGKB IDPA30877
Map Location16q12.2

GO terms in MMP2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004222 metalloendopeptidase activity
MF EXP GO:0004252 serine-type endopeptidase activity
MF TAS GO:0004252 serine-type endopeptidase activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008237 metallopeptidase activity
MF IEA GO:0008270 zinc ion binding
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Gene expression in normal tissue: MMP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined20Apoptosis regulation2Biosynthesis of secondary metabolites2p53 pathway1VEGF signaling pathway1DNA replication1PI3K/MTOR signaling1WNT signaling1Leukocyte transendothelial migration1

Pathways in MMP2


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Database
Pathway ID
Pathway Des.
biocarta reckpathway inhibition of matrix metalloproteinases
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1474228 Degradation of the extracellular matrix
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 4
iGMDRD560 MK-2206 3
iGMDRD1008 SR-II-138A 2
iGMDRD579 PF750 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MMP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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