EIF5A2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 5A2 | MIM:605782 | Ensembl:ENSG00000163577 | HGNC:HGNC:3301 | PA27727 | 3q26.2 |
GO terms in EIF5A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003746 | translation elongation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043022 | ribosome binding |
| BP | IEA | GO:0006452 | translational frameshifting |
| BP | NAS | GO:0007283 | spermatogenesis |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | NAS | GO:0010509 | polyamine homeostasis |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0045901 | positive regulation of translational elongation |
| BP | IEA | GO:0045905 | positive regulation of translational termination |
| BP | IEA | GO:0051028 | mRNA transport |
| CC | IEA | GO:0005643 | nuclear pore |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: EIF5A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF5A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-204626 | Hypusine synthesis from eIF5A-lysine |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD398 | Sepantronium | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF5A2
CLASSFICATION
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