PRKCI


Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C iotaMIM:600539Ensembl:ENSG00000163558HGNC:HGNC:9404PA337683q26.2

GO terms in PRKCI


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005768endosome
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0005923bicellular tight junction
CCIDAGO:0015630microtubule cytoskeleton
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0031252cell leading edge
CCIEAGO:0032991protein-containing complex
CCIEAGO:0043220Schmidt-Lanterman incisure
CCIDAGO:0045171intercellular bridge
CCHDAGO:0070062extracellular exosome
BPIDAGO:0006468protein phosphorylation
BPNASGO:0006612protein targeting to membrane
BPNASGO:0007010cytoskeleton organization
BPIEAGO:0007015actin filament organization
BPIMPGO:0010976positive regulation of neuron projection development
BPTASGO:0016192vesicle-mediated transport
BPIEAGO:0016477cell migration
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPISSGO:0032869cellular response to insulin stimulus
BPIMPGO:0034351negative regulation of glial cell apoptotic process
BPIEAGO:0035089establishment of apical/basal cell polarity
BPIBAGO:0035556intracellular signal transduction
BPIEAGO:0042462eye photoreceptor cell development
BPTASGO:0043066negative regulation of apoptotic process
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPTASGO:0045197establishment or maintenance of epithelial cell apical/basal polarity
BPIMPGO:0045216cell-cell junction organization
BPTASGO:0045747positive regulation of Notch signaling pathway
BPISSGO:0046326positive regulation of glucose import
BPNASGO:0046903secretion
BPIEAGO:0048194Golgi vesicle budding
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0060252positive regulation of glial cell proliferation
BPNASGO:0061024membrane organization
BPIEAGO:0070555response to interleukin-1
BPTASGO:0070830bicellular tight junction assembly
BPISSGO:1903078positive regulation of protein localization to plasma membrane
BPIMPGO:2000353positive regulation of endothelial cell apoptotic process
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFISSGO:0004697protein kinase C activity
MFIPIGO:0005515protein binding
MFTASGO:0005524ATP binding
MFIDAGO:0005543phospholipid binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: PRKCI

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCI


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
pidil1pathwayIL1-mediated signaling events
pidinsulin_glucose_pathwayInsulin-mediated glucose transport
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtnfpathwayTNF receptor signaling pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
netpathPathway_EGFR1EGFR1
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-420029Tight junction interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-73887Death Receptor Signalling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22062
iGMDRD494Neopeltolide3
iGMDRD405PIK-752
iGMDRD151CHM-13
iGMDRD307Manumycin A1
iGMDRD387CHIR-990213
iGMDRD446LY 21832401
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-73
iGMDRD137Indisulam2
iGMDRD255SB2250022
iGMDRD505Pevonedistat3
iGMDRD286Nsc 6328393
iGMDRD871BRD63682
iGMDRD329Merck602
iGMDRD780PP-301
iGMDRD562Navitoclax3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCI

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