PRKCI
Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C iota | MIM:600539 | Ensembl:ENSG00000163558 | HGNC:HGNC:9404 | PA33768 | 3q26.2 |
GO terms in PRKCI
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005768 | endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005923 | bicellular tight junction |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031252 | cell leading edge |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043220 | Schmidt-Lanterman incisure |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006612 | protein targeting to membrane |
| BP | NAS | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0007015 | actin filament organization |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | TAS | GO:0016192 | vesicle-mediated transport |
| BP | IEA | GO:0016477 | cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | IMP | GO:0034351 | negative regulation of glial cell apoptotic process |
| BP | IEA | GO:0035089 | establishment of apical/basal cell polarity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0042462 | eye photoreceptor cell development |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | TAS | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | IMP | GO:0045216 | cell-cell junction organization |
| BP | TAS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | ISS | GO:0046326 | positive regulation of glucose import |
| BP | NAS | GO:0046903 | secretion |
| BP | IEA | GO:0048194 | Golgi vesicle budding |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0060252 | positive regulation of glial cell proliferation |
| BP | NAS | GO:0061024 | membrane organization |
| BP | IEA | GO:0070555 | response to interleukin-1 |
| BP | TAS | GO:0070830 | bicellular tight junction assembly |
| BP | ISS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IMP | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005524 | ATP binding |
| MF | IDA | GO:0005543 | phospholipid binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PRKCI
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCI
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | il1pathway | IL1-mediated signaling events |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | insulin_pathway | Insulin Pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-420029 | Tight junction interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCI
CLASSFICATION
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