NEK11
Summary: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 11 | MIM:609779 | Ensembl:ENSG00000114670 | HGNC:HGNC:18593 | PA38595 | 3q22.1 |
GO terms in NEK11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007059 | chromosome segregation |
| BP | IMP | GO:0016572 | histone phosphorylation |
| BP | IDA | GO:0031573 | intra-S DNA damage checkpoint |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0044772 | mitotic cell cycle phase transition |
| BP | IMP | GO:1901990 | regulation of mitotic cell cycle phase transition |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NEK11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK11
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD144 | NSC95397 | 7 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD151 | CHM-1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK11
CLASSFICATION
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