NEK11

Summary: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameNIMA related kinase 11
OMIM IDMIM:609779
Ensembl IDEnsembl:ENSG00000114670
HGNC IDHGNC:HGNC:18593
PHARMGKB IDPA38595
Map Location3q22.1

GO terms in NEK11


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006468 protein phosphorylation
BP IBA GO:0007059 chromosome segregation
BP IMP GO:0016572 histone phosphorylation
BP IDA GO:0031573 intra-S DNA damage checkpoint
BP IDA GO:0035556 intracellular signal transduction
BP IMP GO:0044772 mitotic cell cycle phase transition
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Gene expression in normal tissue: NEK11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined18WNT signaling1Cell cycle1Stilbenoid, diarylheptanoid and gingerol biosynthesis1ERK MAPK signaling1

Pathways in NEK11


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 2
iGMDRD505 Pevonedistat 2
iGMDRD60 Quinoclamine 5
iGMDRD188 Piperlongumine 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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