MAP3K6

Summary: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 6
OMIM IDMIM:604468
Ensembl IDEnsembl:ENSG00000142733
HGNC IDHGNC:HGNC:6858
PHARMGKB IDPA30602
Map Location1p36.11

GO terms in MAP3K6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000287 magnesium ion binding
MF IBA GO:0004672 protein kinase activity
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IDA GO:0004709 MAP kinase kinase kinase activity
MF IDA GO:0005524 ATP binding
BP IBA GO:0000186 activation of MAPKK activity
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Gene expression in normal tissue: MAP3K6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15Proteasome1Longevity regulating pathway1DNA replication1Biosynthesis of secondary metabolites1Apoptosis regulation1ERK MAPK signaling1

Pathways in MAP3K6


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Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
pid p38_mkk3_6pathway p38 MAPK signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 2
iGMDRD562 Navitoclax 2
iGMDRD188 Piperlongumine 2
iGMDRD286 Nsc 632839 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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