MAP3K6
Summary: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 6 | MIM:604468 | Ensembl:ENSG00000142733 | HGNC:HGNC:6858 | PA30602 | 1p36.11 |
GO terms in MAP3K6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IDA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
| BP | IBA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| CC | IEA | GO:0005622 | intracellular |
Gene expression in normal tissue: MAP3K6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD427 | ABT737 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K6
CLASSFICATION
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