DDX6


Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DEAD-box helicase 6MIM:600326Ensembl:ENSG00000110367HGNC:HGNC:2747PA2722911q23.3

GO terms in DDX6


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFTASGO:0003724RNA helicase activity
MFTASGO:0004386helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019904protein domain specific binding
MFHDAGO:0045296cadherin binding
BPIEAGO:0007283spermatogenesis
BPIMPGO:0019074viral RNA genome packaging
BPIEAGO:0019827stem cell population maintenance
BPIDAGO:0033962cytoplasmic mRNA processing body assembly
BPTASGO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
BPIEAGO:0045665negative regulation of neuron differentiation
CCIEAGO:0000792heterochromatin
CCIDAGO:0000932P-body
CCIMPGO:0000932P-body
CCIEAGO:0001520outer dense fiber
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0010494cytoplasmic stress granule
CCHDAGO:0016020membrane
CCIDAGO:0016442RISC complex
CCIDAGO:0036464cytoplasmic ribonucleoprotein granule
CCIEAGO:0043186P granule
CCIEAGO:0097227sperm annulus

Gene expression in normal tissue: DDX6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX6


DatabasePathway IDPathway Des.
reactomeR-HSA-429914Deadenylation-dependent mRNA decay
reactomeR-HSA-430039mRNA decay by 5' to 3' exoribonuclease
reactomeR-HSA-8953854Metabolism of RNA
netpathPathway_EGFR1EGFR1
kegghsa03018RNA degradation - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD147Prima-11
iGMDRD780PP-302
iGMDRD398Sepantronium3
iGMDRD506Fedratinib2
iGMDRD887Compound 23 citrate3
iGMDRD188Piperlongumine3
iGMDRD52Rotenone2
iGMDRD870BRD636103
iGMDRD434BMS-5369242
iGMDRD289Parthenolide2
iGMDRD227Fatostatin A2
iGMDRD251ML1623
iGMDRD280CYTOCHALASIN B6
iGMDRD394BX-7952
iGMDRD405PIK-751
iGMDRD494Neopeltolide2
iGMDRD427ABT7373
iGMDRD144NSC953973
iGMDRD546BMS-7548072
iGMDRD772BRD47702
iGMDRD512nutlin 31
iGMDRD126Tipifarnib5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX6

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