DDX6
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DEAD-box helicase 6 | MIM:600326 | Ensembl:ENSG00000110367 | HGNC:HGNC:2747 | PA27229 | 11q23.3 |
GO terms in DDX6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003724 | RNA helicase activity |
| MF | TAS | GO:0004386 | helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IMP | GO:0019074 | viral RNA genome packaging |
| BP | IEA | GO:0019827 | stem cell population maintenance |
| BP | IDA | GO:0033962 | cytoplasmic mRNA processing body assembly |
| BP | TAS | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| CC | IEA | GO:0000792 | heterochromatin |
| CC | IDA | GO:0000932 | P-body |
| CC | IMP | GO:0000932 | P-body |
| CC | IEA | GO:0001520 | outer dense fiber |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016442 | RISC complex |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| CC | IEA | GO:0043186 | P granule |
| CC | IEA | GO:0097227 | sperm annulus |
Gene expression in normal tissue: DDX6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDX6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD227 | Fatostatin A | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD126 | Tipifarnib | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDX6
CLASSFICATION
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