Summary: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

TNF receptor superfamily member 13BMIM:604907Ensembl:ENSG00000240505HGNC:HGNC:18153PA3850917p11.2

GO terms in TNFRSF13B

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
BPIBAGO:0001782B cell homeostasis
BPIBAGO:0002244hematopoietic progenitor cell differentiation
BPIEAGO:0002250adaptive immune response
BPTASGO:0007166cell surface receptor signaling pathway
BPIBAGO:0030889negative regulation of B cell proliferation
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
MFIPIGO:0005515protein binding
MFTASGO:0038023signaling receptor activity

Gene expression in normal tissue: TNFRSF13B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF13B

DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors
biocartatall1pathwayyaci and bcma stimulation of b cell immune responses

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF13B