TNFRSF13B
Summary: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 13B | MIM:604907 | Ensembl:ENSG00000240505 | HGNC:HGNC:18153 | PA38509 | 17p11.2 |
GO terms in TNFRSF13B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| BP | IBA | GO:0001782 | B cell homeostasis |
| BP | IBA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0030889 | negative regulation of B cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: TNFRSF13B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF13B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| biocarta | tall1pathway | yaci and bcma stimulation of b cell immune responses |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD427 | ABT737 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF13B
CLASSFICATION
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