TNFRSF13B


Summary: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

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GO terms in TNFRSF13B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IEA GO:0005887 integral component of plasma membrane
BP IBA GO:0001782 B cell homeostasis
BP IBA GO:0002244 hematopoietic progenitor cell differentiation
BP IEA GO:0002250 adaptive immune response
BP TAS GO:0007166 cell surface receptor signaling pathway
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Gene expression in normal tissue: TNFRSF13B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF13B


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Database
Pathway ID
Pathway Des.
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
kegg hsa05340 Primary immunodeficiency - Homo sapiens (human)
pid syndecan_2_pathway Syndecan-2-mediated signaling events
pid syndecan_4_pathway Syndecan-4-mediated signaling events
reactome R-HSA-1280215 Cytokine Signaling in Immune system
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 6
iGMDRD137 Indisulam 3
iGMDRD801 2,4-dideoxy-DC-45-A2 3
iGMDRD427 ABT737 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF13B

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Model
Level
Reference ID
Tissue
Cancer
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Clinical Response
Source
No matching records found

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