PTPN22
Summary: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, non-receptor type 22 | MIM:600716 | Ensembl:ENSG00000134242 | HGNC:HGNC:9652 | PA33995 | 1p13.2 |
GO terms in PTPN22
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0006914 | autophagy |
| BP | IMP | GO:0010507 | negative regulation of autophagy |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | ISS | GO:0030217 | T cell differentiation |
| BP | IMP | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0032481 | positive regulation of type I interferon production |
| BP | IMP | GO:0032496 | response to lipopolysaccharide |
| BP | IMP | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032817 | regulation of natural killer cell proliferation |
| BP | IMP | GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway |
| BP | IMP | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | ISS | GO:0035644 | phosphoanandamide dephosphorylation |
| BP | IMP | GO:0043508 | negative regulation of JUN kinase activity |
| BP | IC | GO:0045088 | regulation of innate immune response |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | NAS | GO:0050855 | regulation of B cell receptor signaling pathway |
| BP | IDA | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | IMP | GO:0050868 | negative regulation of T cell activation |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | IDA | GO:0071225 | cellular response to muramyl dipeptide |
| BP | IMP | GO:1900165 | negative regulation of interleukin-6 secretion |
| BP | IMP | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1902523 | positive regulation of protein K63-linked ubiquitination |
| BP | IMP | GO:1902715 | positive regulation of interferon-gamma secretion |
| BP | IMP | GO:1903753 | negative regulation of p38MAPK cascade |
| BP | IMP | GO:2000483 | negative regulation of interleukin-8 secretion |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0009898 | cytoplasmic side of plasma membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016791 | phosphatase activity |
| MF | ISS | GO:0017124 | SH3 domain binding |
| MF | ISS | GO:0019900 | kinase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
Gene expression in normal tissue: PTPN22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPN22
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
| reactome | R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD202 | Curcumin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPN22
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.