ITGB6
Summary: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit beta 6 | MIM:147558 | Ensembl:ENSG00000115221 | HGNC:HGNC:6161 | PA29960 | 2q24.2 |
GO terms in ITGB6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0008305 | integrin complex |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0030054 | cell junction |
| CC | IBA | GO:0034685 | integrin alphav-beta6 complex |
| CC | IEA | GO:0034685 | integrin alphav-beta6 complex |
| CC | IDA | GO:0043235 | receptor complex |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007160 | cell-matrix adhesion |
| BP | IEA | GO:0007160 | cell-matrix adhesion |
| BP | IBA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IBA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEA | GO:0038044 | transforming growth factor-beta secretion |
| BP | IEA | GO:0046718 | viral entry into host cell |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0005178 | integrin binding |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: ITGB6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGB6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | integrin5_pathway | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2911 | miRNA targets in ECM and membrane receptors |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD131 | Erlotinib | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD409 | Saracatinib | 2 |
| iGMDRD486 | Tosedostat | 4 |
| iGMDRD427 | ABT737 | 8 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD781 | Sirolimus | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGB6
CLASSFICATION
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