COLEC12
Summary: This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607621 Ensembl IDEnsembl:ENSG00000158270 HGNC IDHGNC:HGNC:16016 PHARMGKB IDPA26738 Map Location18p11.32 | |||||
GO terms in COLEC12
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | IDA | GO:0006910 | phagocytosis, recognition |
| BP | TAS | GO:0006952 | defense response |
| BP | NAS | GO:0009756 | carbohydrate mediated signaling |
| BP | IBA | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0034138 | toll-like receptor 3 signaling pathway |
Gene expression in normal tissue: COLEC12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COLEC12
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-3000480 | Scavenging by Class A Receptors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COLEC12
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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