SCYL1
Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SCY1 like pseudokinase 1 | MIM:607982 | Ensembl:ENSG00000142186 | HGNC:HGNC:14372 | PA31812 | 11q13.1 |
GO terms in SCYL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| CC | IEA | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005801 | cis-Golgi network |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030126 | COPI vesicle coat |
| MF | IEA | GO:0003677 | DNA binding |
| MF | NAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: SCYL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCYL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD351 | GW843682X | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCYL1
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