MAPKBP1
Summary: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase binding protein 1 | MIM:616786 | Ensembl:ENSG00000137802 | HGNC:HGNC:29536 | PA142671479 | 15q15.1 |
GO terms in MAPKBP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0097431 | mitotic spindle pole |
| BP | IMP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:1900425 | negative regulation of defense response to bacterium |
| BP | IMP | GO:2000483 | negative regulation of interleukin-8 secretion |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MAPKBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPKBP1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD441 | TW 37 | 5 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD901 | ELCPK | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPKBP1
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