MAPKBP1


Summary: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase binding protein 1MIM:616786Ensembl:ENSG00000137802HGNC:HGNC:29536PA14267147915q15.1

GO terms in MAPKBP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIDAGO:0097431mitotic spindle pole
BPIMPGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:1900425negative regulation of defense response to bacterium
BPIMPGO:2000483negative regulation of interleukin-8 secretion
MFIPIGO:0005515protein binding

Gene expression in normal tissue: MAPKBP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPKBP1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A2
iGMDRD441TW 375
iGMDRD192CIL563
iGMDRD121GMX17783
iGMDRD23Gossypol3
iGMDRD64Parbendazole3
iGMDRD872BRD71373
iGMDRD414MST-3124
iGMDRD871BRD63683
iGMDRD188Piperlongumine6
iGMDRD286Nsc 6328396
iGMDRD781Sirolimus4
iGMDRD427ABT7373
iGMDRD772BRD47703
iGMDRD889Compound 7d-cis3
iGMDRD433Lexibulin2
iGMDRD280CYTOCHALASIN B3
iGMDRD394BX-7953
iGMDRD901ELCPK1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPKBP1

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