MAPKBP1

Summary: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase binding protein 1
OMIM IDMIM:616786
Ensembl IDEnsembl:ENSG00000137802
HGNC IDHGNC:HGNC:29536
PHARMGKB IDPA142671479
Map Location15q15.1

GO terms in MAPKBP1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005737 cytoplasm
CC IDA GO:0097431 mitotic spindle pole
BP IMP GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
BP IMP GO:1900425 negative regulation of defense response to bacterium
BP IMP GO:2000483 negative regulation of interleukin-8 secretion
MF IPI GO:0005515 protein binding
Showing 1 to 6 of 6 rows

Gene expression in normal tissue: MAPKBP1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 32LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 21OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 5BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined16Longevity regulating pathway1Apoptosis regulation1Biosynthesis of secondary metabolites1

Pathways in MAPKBP1


Loading, please wait...
Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD267 Oligomycin A 2
iGMDRD441 TW 37 5
iGMDRD192 CIL56 3
iGMDRD121 GMX1778 3
Showing 1 to 4 of 19 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPKBP1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.