STK32B
Summary: This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 32B | Ensembl:ENSG00000152953 | HGNC:HGNC:14217 | PA128394683 | 4p16.2 |
GO terms in STK32B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: STK32B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK32B
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD48 | Dexamethasone | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD375 | GW-405833 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK32B
CLASSFICATION
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