TRIM37
Summary: This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 37 | MIM:605073 | Ensembl:ENSG00000108395 | HGNC:HGNC:7523 | PA35497 | 17q22 |
GO terms in TRIM37
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0035518 | histone H2A monoubiquitination |
| BP | IDA | GO:0036353 | histone H2A-K119 monoubiquitination |
| BP | IMP | GO:0046600 | negative regulation of centriole replication |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051865 | protein autoubiquitination |
| BP | IDA | GO:0070842 | aggresome assembly |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005777 | peroxisome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016235 | aggresome |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: TRIM37
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM37
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD441 | TW 37 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM37
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