ITGA7
Summary: The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 7 | MIM:600536 | Ensembl:ENSG00000135424 | HGNC:HGNC:6143 | PA29943 | 12q13.2 |
GO terms in ITGA7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0008305 | integrin complex |
| CC | IC | GO:0009986 | cell surface |
| BP | TAS | GO:0007160 | cell-matrix adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007517 | muscle organ development |
| BP | IEA | GO:0008360 | regulation of cell shape |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0034113 | heterotypic cell-cell adhesion |
| BP | IEP | GO:0035987 | endodermal cell differentiation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ITGA7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD154 | NSC23766 | 7 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD271 | Brefeldin A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA7
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