ITGA7

Summary: The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameintegrin subunit alpha 7
OMIM IDMIM:600536
Ensembl IDEnsembl:ENSG00000135424
HGNC IDHGNC:HGNC:6143
PHARMGKB IDPA29943
Map Location12q13.2

GO terms in ITGA7


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IEA GO:0008305 integrin complex
CC IC GO:0009986 cell surface
BP TAS GO:0007160 cell-matrix adhesion
BP IEA GO:0007229 integrin-mediated signaling pathway
BP TAS GO:0007517 muscle organ development
Showing 1 to 6 of 12 rows rows per page

Gene expression in normal tissue: ITGA7

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 81LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13

Gene-drug pathway distribution

undefined27Mitosis1PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Th17 cell differentiation1Apoptosis regulation1Longevity regulating pathway1Biosynthesis of secondary metabolites1Other, kinases1

Pathways in ITGA7


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP185 Integrin-mediated Cell Adhesion
wikipathways WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways WP306 Focal Adhesion
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 22 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD679 Bistramide A 3
iGMDRD316 N9-Isopropyl-olomoucine 2
iGMDRD639 YK 4-279 3
iGMDRD446 LY 2183240 3
Showing 1 to 4 of 35 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA7

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.