SDHB


Summary: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].

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Name
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Gene Categories:

CLINICALLY ACTIONABLE

GO terms in SDHB


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IEA GO:0008177 succinate dehydrogenase (ubiquinone) activity
MF IEA GO:0009055 electron transfer activity
MF IEA GO:0046872 metal ion binding
MF ISS GO:0048039 ubiquinone binding
MF ISS GO:0051537 2 iron, 2 sulfur cluster binding
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Gene expression in normal tissue: SDHB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined6Cell cycle1Protein stability and degradation1DNA replication1

Pathways in SDHB


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
reactome R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1430728 Metabolism
reactome R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
reactome R-HSA-611105 Respiratory electron transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD105 Triptolide 3
iGMDRD427 ABT737 1
iGMDRD701 NVP-AUY922 6
iGMDRD103 SN-38 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SDHB

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Model
Level
Reference ID
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Cancer
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Source
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