SDHB
Summary: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:185470 Ensembl IDEnsembl:ENSG00000117118 HGNC IDHGNC:HGNC:10681 PHARMGKB IDPA35606 Map Location1p36.13 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in SDHB
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008177 | succinate dehydrogenase (ubiquinone) activity |
MF | IEA | GO:0009055 | electron transfer activity |
MF | IEA | GO:0046872 | metal ion binding |
MF | ISS | GO:0048039 | ubiquinone binding |
MF | ISS | GO:0051537 | 2 iron, 2 sulfur cluster binding |
Gene expression in normal tissue: SDHB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SDHB
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
reactome | R-HSA-611105 | Respiratory electron transport |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SDHB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |