BRCC3


Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BRCA1/BRCA2-containing complex subunit 3MIM:300617Ensembl:ENSG00000185515HGNC:HGNC:24185PA134922847Xq28

GO terms in BRCC3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIMPGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIPIGO:0005515protein binding
MFIBAGO:0008237metallopeptidase activity
MFIMPGO:0008237metallopeptidase activity
MFIDAGO:0030234enzyme regulator activity
MFIBAGO:0031593polyubiquitin modification-dependent protein binding
MFIDAGO:0031593polyubiquitin modification-dependent protein binding
MFIBAGO:0036459thiol-dependent ubiquitinyl hydrolase activity
MFIMPGO:0036459thiol-dependent ubiquitinyl hydrolase activity
MFIEAGO:0046872metal ion binding
MFTASGO:0061578Lys63-specific deubiquitinase activity
CCIDAGO:0000151ubiquitin ligase complex
CCIDAGO:0000152nuclear ubiquitin ligase complex
CCIEAGO:0000922spindle pole
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0070531BRCA1-A complex
CCIDAGO:0070531BRCA1-A complex
CCIBAGO:0070552BRISC complex
CCIDAGO:0070552BRISC complex
BPIBAGO:0006281DNA repair
BPIBAGO:0006302double-strand break repair
BPIMPGO:0006302double-strand break repair
BPTASGO:0006303double-strand break repair via nonhomologous end joining
BPIEAGO:0007049cell cycle
BPIDAGO:0010165response to X-ray
BPIMPGO:0010212response to ionizing radiation
BPTASGO:0016579protein deubiquitination
BPIMPGO:0045739positive regulation of DNA repair
BPIEAGO:0050790regulation of catalytic activity
BPIEAGO:0051301cell division
BPIBAGO:0070536protein K63-linked deubiquitination
BPIDAGO:0070536protein K63-linked deubiquitination
BPIMPGO:0070536protein K63-linked deubiquitination
BPIBAGO:0070537histone H2A K63-linked deubiquitination
BPIDAGO:0070537histone H2A K63-linked deubiquitination
BPIMPGO:0070537histone H2A K63-linked deubiquitination
BPIMPGO:0072425signal transduction involved in G2 DNA damage checkpoint

Gene expression in normal tissue: BRCC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRCC3


DatabasePathway IDPathway Des.
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689901Metalloprotease DUBs
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B3
iGMDRD123Isoevodiamine2
iGMDRD61Kinetin riboside2
iGMDRD781Sirolimus1
iGMDRD427ABT7373
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib5
iGMDRD307Manumycin A3
iGMDRD64Parbendazole6
iGMDRD60Quinoclamine1
iGMDRD888Compound 4410
iGMDRD577BIX012944
iGMDRD562Navitoclax9
iGMDRD780PP-302
iGMDRD366PI-1031
iGMDRD871BRD63684
iGMDRD188Piperlongumine2
iGMDRD872BRD71371
iGMDRD318PAC-12
iGMDRD434BMS-5369242
iGMDRD255SB2250022

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRCC3

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